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Reliable, unbiased and up to date information in cancer research

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MSU-42011 is an Orally Active RXR Agonist for Cancer Research

Louis Gilman September 1, 2023

The retinoid X receptor (RXR) belongs to the nuclear receptor superfamily. The nuclear receptors superfamily has many other nuclear receptors, including the retinoic acid receptor (RAR), vitamin D receptor (VDR),…

Lung Cancer Non-Small Cell Lung Cancer

Osimertinib (AZD9291) is an Orally Active EGFR Inhibitor for Lung Cancer Research

Louis Gilman August 31, 2023

EGFR-mutated (EGFRm+) non-small cell lung cancer (NSCLC) is a major clinical problem. Tyrosine kinase inhibitors (TKIs) have precision therapeutic implications for advanced NSCLC. However, common EGFR mutations, such as EGFRL858R,…

Lung Cancer

Elesclomol (STA-4783) is a Potent Copper Ionophore and Promotes Cuproptosis (Copper-dependent cell death)

Louis Gilman June 20, 2023

Cuproptosis is a unique type of cell death that is copper-dependent. Copper is a double-edged sword. On the one hand, it is an important enzyme cofactor. On the other hand,…

Lung Cancer

Glochidiol is an Orally Active Tubulin Polymerization Inhibitor for Lung Cancer Research

Louis Gilman May 25, 2023

Tubulin is the protein that polymerizes into long chains or filaments that form microtubules, hollow fibers which serve as a skeletal system for living cells. Importantly, Tubulin includes α- and…

Lung Cancer

CFL-137 is a Potent KRasG12C Inhibitor for Lung Cancer Research

Louis Gilman May 19, 2023

KRas (Kirsten rat sarcoma virus) is a part of the RAS/MAPK pathway and relays signals from outside the cell to the cell's nucleus. Importantly, KRasG12C is a mutation of KRas.…

Breast Cancer Cancer HER2+ Breast Cancer Lung Cancer Non-Small Cell Lung Cancer

Capivasertib (AZD5363) is an Orally Active and Potent Pan-AKT Kinase Inhibitor

Louis Gilman May 4, 2023

ATR kinase is a key component of the DNA damage response pathway. Additionally, it plays a critical role in maintaining genome stability. Ceralasertib (AZD6738) is a potent inhibitor of ATR…

Cancer Large Cell Lung Cancer Lung Cancer Non-Small Cell Lung Cancer

RMC-6291 is an Orally Active and Covalent KRASG12C Inhibitor for Solid Tumor Research

Louis Gilman April 26, 2023

KRAS  plays a critical role in regulating cell growth and division. KRAS mutations are common in many types of solid tumors, including lung, colon, and pancreatic cancers, and are associated…

Cancer Colon Cancer Colorectal Cancer Lung Cancer Non-Small Cell Lung Cancer

Izalontamab (SI-B001) is a Bispecific Anti-EGFR/HER3 mAb for Cancer Research

Louis Gilman March 15, 2023

EGFR (epidermal growth factor receptor) is a member of the ErbB receptor family1. Besides, EGFR is a common therapeutic strategy in epithelioma such as lung adenocarcinoma, colon cancer, head and…

Cancer Colorectal Cancer Lung Adenocarcinoma Lung Cancer NSCLC

Sotorasib (AMG-510) is an Orally Bioavailable KRAS G12C Covalent Inhibitor

Louis Gilman March 10, 2023

The KRAS oncoprotein is a GTPase and an essential mediator of intracellular signaling pathways. KRAS oncoprotein regulates tumor cell growth and survival. However, KRAS also is the most frequently mutated…

Lung Cancer

Amivantamab (JNJ-61186372) is a Human EGFR-MET Bispecific Antibody

Louis Gilman January 16, 2023

Epidermal growth factor (EGF) is a protein that stimulates cell proliferation, differentiation, and survival by binding to its receptor EGFR. Additionally, It exists in platelets, urine, saliva, milk, tears, and…

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Breast Cancer

BI 7446 is a STING Agonist for Immuno-oncology Research

Gastric Cancer Obesity

JNJ-38877605 is an Orally Active c-Met Inhibitor for Solid Tumour Research

Multiple Myeloma Myeloma

OATD-02 is an Orally Active Arginase 1/2 Inhibitor for Melanoma Research

autoimmune disease

INCB086550 is an Orally Active PD-L1 Inhibitor for Multiple Cancers Research

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