PROTACs are bi-functional molecules, capable of concurrently binding to target proteins of interest and the subunits of E3 ligases, such as Cereblon, VHL, and MDM2, among others. In short, Cooperative…
Proteolysis targeting chimeras (PROTAC) is a bifunctional molecule that could draw an E3 ubiquitin ligase close to a protein of interest (POI) and induce its degradation via the ubiquitin-proteasome system…
Farnesyltransferase (farnesyltransferase, FTase) is composed of the α subunit encoded by the FNTA gene and the β subunit encoded by the FNTB gene. FTase recognizes the C-terminal CAAX motif of…
SRPIN803 can prevent VEGF production owing to the dual inhibition of SRPK1 and CK2. SRPKs are a critical enzyme family that regulates splicing activity in the cell. Serine-arginine protein kinase…
mTOR is the target of Rapamycin. In the early 1990s, genetic screens in budding yeast identified the TOR1 and TOR2 genes as mediators of the toxic effects of Rapamycin on…
ATM (ataxia-telangiectasia mutated) is a serine/threonine protein kinase that is recruited and activated by DNA double-strand breaks. Importantly, In response to DSB, the ATM kinase undergoes autophosphorylation and subsequently phosphorylates…
MY-943 is a potent tubulin polymerization and LSD1 inhibitor with anticancer activity. Tubulin in molecular biology can refer either to the tubulin protein superfamily of globular proteins, or one of…
Cuproptosis is a unique type of cell death that is copper-dependent. Copper is a double-edged sword. On the one hand, it is an important enzyme cofactor. On the other hand,…
Bruton tyrosine kinase (BTK) is a non-receptor kinase that plays a crucial role in carcinogenic signaling. Meanwhile, it plays a central role in the signal transduction of B cell antigen…
Ras proteins play a crucial role in tumor diseases. Farnesylation is an important post-translational modification of Ras proteins. Whereas, that determines the oncogenicity and membrane-binding properties of Ras. Meanwhile, Farnesyltransferase…