AZD-9574 is a potent and brain penetrant PARP1 inhibitor
The Poly (ADP-ribose) polymerase (PARP) family has numerous essential functions. PARP plays roles in cellular processes such as transcription, chromatin remodeling, DNA damage response, and repair. DNA double-strand breaks (DSBs) are the most deleterious form of DNA damage. Besides, DSBs can be repaired by homologous recombination repair (HRR) or...
Lapatinib is a Potent Inhibitor of the ErbB-2 and EGFR Tyrosine Kinase Domains
Growth factors and their transmembrane receptor tyrosine kinase play important roles in cell proliferation, survival, migration, and differentiation. Additionally, Epidermal growth factor (EGF)-like proteins stimulates cells to divide by activating members of the EGF receptor (EGFR) family. Many types of human tumor cells growth and development are related to the...
Capivasertib (AZD5363) is an Orally Active pan-AKT Kinase Inhibitor
Akt/PKB (Protein kinase B), usually called Akt, is a serine/threonine protein kinase with antiapoptotic activity. In addition, Akt consists of three isoforms: PKBα/Akt1, PKBβ/Akt2 and PKBγ/Akt3. Catalytically active Akt regulates the function of numerous substrates involved in cell survival, growth, proliferation, metabolism and protein synthesis. Akt possesses a protein...
AZD-9833 is an Orally Active Estrogen Receptor (ER) Antagonist
Estrogens participate in numerous physiological processes such as cell growth, reproduction, and differentiation. In females, the ovaries are the major site of estrogen synthesis producing the predominant estrogen 17b-estradiol (E2). In addition to effects by E2 on normal physiology, estrogens also play an important role in several pathological processes...