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Reliable, unbiased and up to date information in cancer research

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Chronic Lymphocytic Leukemia Lymphoma Mantle Cell Lymphoma

Ibrutinib is a Btk Inhibitor for Autoimmune Disease and B-cell Malignancy Research

Louis Gilman July 17, 2023

Bruton tyrosine kinase (Btk), a non-receptor kinase, is a member of the Tec family kinases. Btk is exists in B cells and myeloid cells. Btk has a carboxy-terminal catalytic domain…

Cancer Chronic Lymphocytic Leukemia

MU380 is a CHK1 Inhibitor for the Research of Chronic Lymphocytic Leukemia

Louis Gilman July 4, 2023

Checkpoint kinase 1 (Chk1) is a conserved protein kinase that is critical to the Cell cycle checkpoint during DNA damage response (DDR). Specifically, CHK1 is the regulatory factor for G2/M…

Chronic Lymphocytic Leukemia Leukemia Lymphoma Non-Hodgkin Lymphoma

Tirabrutinib is a Selective BTK Inhibitor

Louis Gilman January 18, 2022

The BTK kinases comprise 5 structural domains, including pleckstrin homology, TEC homology, Src homology, Src homology, and kinase domains. The activation of BTK kinase depends on recruitment to the plasma…

Acute Myeloid Leukemia Chronic Lymphocytic Leukemia

Flavopiridol (Alvocidib) is a pan CDK Inhibitor

Louis Gilman December 4, 2021

The cyclin-dependent kinases (CDKs) are serine/threonine protein kinases. And it exhibits drives force behind the cell cycle and cell proliferation. CDKs contain at least a catalytic subunit (CDK) and a…

Chronic Lymphocytic Leukemia Leukemia Pancreas Cancer

Ruxolitinib (INCB018424) is an Orally Active JAK1 and JAK2 Inhibitor

Louis Gilman September 4, 2021

The myeloproliferative neoplasms (MPNs) are a group of related clonal diseases probably arising from hematopoietic progenitor or stem cells. Patients with MPNs have an increased risk of thrombotic and bleeding…

Chronic Lymphocytic Leukemia

GSK143 is an Orally Active and Highly Selective Spleen Tyrosine Kinase (SYK) Inhibitor

Louis Gilman July 7, 2020

Tyrosine-protein kinase SYK is an enzyme that in humans is encoded by the SYK gene. Specifically, Syk is a 72 kDa cytoplasmic non-receptor tyrosine kinase and it is relevant to…

Chronic Lymphocytic Leukemia

WZ811 is an Orally Active CXCR4 Antagonist

Louis Gilman September 7, 2019

The C-X-C chemokine receptor-4 (CXCR4) is a seven-transmembrane G-protein coupled receptor (GPCR). It is a member of the family I GPCR or rhodopsin-like GPCR family. The chemokine stromal cell-derived factor-1…

Chronic Lymphocytic Leukemia Melanoma

NXT629 is a Selective and Competitive PPARα Antagonist

Louis Gilman August 18, 2019

Peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription factors that belong to the nuclear hormone receptor superfamily. Of these, PPARα mainly expresses in the liver, where it activates fatty acid catabolism.…

Acute Myeloid Leukemia Chronic Lymphocytic Leukemia

TAK-659 is a Dual SYK and FLT-3 Kinase Inhibitor for Leukemia Treatment

Louis Gilman August 8, 2019

Acute Myelogenous Leukemia (AML) is a disease driven by SYK and/or FLT3-mediated signaling. In particular, spleen tyrosine kinase (SYK) is a 72 kD non-receptor cytoplasmic tyrosine kinase. SYK is a…

Chronic Lymphocytic Leukemia

MT-802 is a PROTAC Degrader of BTK for C481S Mutant CLL Treatment

Louis Gilman July 30, 2019

The irreversible inhibitor Ibrutinib for Bruton’s tyrosine kinase (BTK) has emerged as a transformative treatment option for patients with chronic lymphocytic leukemia (CLL) and other B-cell malignancies. However, more than…

Recent Posts

  • BI 7446 is a STING Agonist for Immuno-oncology Research
  • JNJ-38877605 is an Orally Active c-Met Inhibitor for Solid Tumour Research
  • OATD-02 is an Orally Active Arginase 1/2 Inhibitor for Melanoma Research
  • INCB086550 is an Orally Active PD-L1 Inhibitor for Multiple Cancers Research
  • Panobinostat is a HDAC Inhibitor for Multiple Myeloma Research

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You Missed

Breast Cancer

BI 7446 is a STING Agonist for Immuno-oncology Research

Gastric Cancer Obesity

JNJ-38877605 is an Orally Active c-Met Inhibitor for Solid Tumour Research

Multiple Myeloma Myeloma

OATD-02 is an Orally Active Arginase 1/2 Inhibitor for Melanoma Research

autoimmune disease

INCB086550 is an Orally Active PD-L1 Inhibitor for Multiple Cancers Research

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