Nanrilkefusp alfa is a Selective and Potent Agonist Fusion Protein of IL-15.
IL-15 is a cytokine involved in the regulation of the innate immune system. It stimulates the proliferation and activation of natural killer (NK) cells and memory CD8+ T cells. And also it promotes the secretion of a variety of cytokines. Moreover, IL-15 enhances the antibody-dependent cytotoxicity (ADCC) of antibodies. Specifically,...
BLU2864 is An Orally Active PRKACA Kinase Inhibitor
Fibrolamellar carcinoma (FLC) is a rare, difficult-to-treat liver cancer primarily affecting pediatric and adolescent patients. An analysis of FLC tumor samples shows that protein kinase A (PKA) alpha catalytic subunit (PRKACA) is a critical molecular event in FLC pathogenesis. In this article, we will introduce an orally active, highly selective, ATP-competitive PRKACA...
Axitinib is a Multi-Targeted Tyrosine Kinase Inhibitor
Vascular endothelial growth factor (VEGF) is an important signal protein. Importantly, it is involved in angiogenesis and angiogenesis (blood vessels grow from a pre-existing vascular system). All members of VEGF family stimulate cell response by binding to tyrosine kinase receptors (VEGFRs) on the cell surface. Thus they dimerize and...
CPTH2 is a Potent Histone Acetyltransferase (HAT) Inhibitor
Histone acetyltransferase (HATS) is an enzyme that acetylates the conserved lysine amino acids in histones by transferring acetyl from acetyl coenzyme A toε-N-acetyllysine. Several chromatin modifiers are responsible for adding different post-translational marks like acetylation, methylation, phosphorylation. Specifically, HATS add lysine at the N-terminal of acetyl histones H3 and...
BI-4924 is a Selective PHGDH Inhibitor
Phosphoglycerate dehydrogenase (PHGDH) is an essential enzyme catalyzing the synthesis of amino acid serine. PHGDH is important for maintaining the poorly differentiated, stem-like state of cancer stem-like cells (CSLCs). Typically, high levels of PHGDH associate with enhanced proliferation and poor prognosis in various types of cancers. As a result,...
SBI-0206965, a ULK1 Inhibitor, Triggers Apoptosis by Preventing Autophagy and PPP Flux
Autophagy is a central cellular mechanism for the elimination of damaged proteins, protein complexes, and organelles. ATG1 gene is notable for being the only core autophagy gene to encode a serine/threonine kinase. Atg1 forms a complex with multiple regulatory subunits, including Atg13 and Atg17. In mammals, there are two Atg1...