BI-4924 is a Selective PHGDH Inhibitor
Phosphoglycerate dehydrogenase (PHGDH) is an essential enzyme catalyzing the synthesis of amino acid serine. PHGDH is important for maintaining the poorly differentiated, stem-like state of cancer stem-like cells (CSLCs). Typically, high levels of PHGDH associate with enhanced proliferation and poor prognosis in various types of cancers. As a result,...
SBI-0206965, a ULK1 Inhibitor, Triggers Apoptosis by Preventing Autophagy and PPP Flux
Autophagy is a central cellular mechanism for the elimination of damaged proteins, protein complexes, and organelles. ATG1 gene is notable for being the only core autophagy gene to encode a serine/threonine kinase. Atg1 forms a complex with multiple regulatory subunits, including Atg13 and Atg17. In mammals, there are two Atg1...