Breast cancer is the most common cancer in women all over the world. Breast cancer development is associated with abnormal cell proliferation and defects in apoptosis. Noticeably, Polo-like Kinases (PLKs)…
IGF2BP2, also known as IMP2, is a member of the insulin-like growth factor 2 messenger RNA-binding protein (IGF2BP) family that is highly conserved in vertebrates. Besides, it was first identified…
Aurora kinases belong to serine/threonine kinases. Aurora kinases control multiple events during cell cycle progression and are essential for mitotic and meiotic bipolar spindle assembly and function. This family contains…
MNKs (Mitogen-activated protein kinase interacting kinases) belong to the family of Ser/Thr kinases, and are classified as members of Ca2+/calmodulin-dependent kinases. MNKs have two different isoforms (MNK1 and MNK2) and…
In this article, we will introduce a potent humanized IgG4k monoclonal antibody against programmed death-1 (PD-1) Geptanolimab. As a result, Geptanolimab inhibits the binding of PD-L1/L2 to PD-1 through a…
Histone deacetylase (HDAC) is an epigenetic enzyme that regulates gene expression through histone deacetylation. It leads to more closed chromatin structure and gene expression inhibition. Many non-histones are also targets…
Ph+ ALL (Philadelphia chromosome-positive acute lymphoblastic leukemia) is a rare subtype of leukemia characterized by the abnormal formation of the Philadelphia chromosome, which occurs when pieces of chromosomes 9 and…
C-C Motif Chemokine Receptor 4 (CCR4) is a G-coupled-protein receptor for C-C chemokines. It's on surface of tumor cells in leukemia and lymphoma patients. For example, adult T-cell leukemia-lymphoma (ATLL),…
Histone deacetylase (HDAC) is an enzyme that catalyzes the removal of acetyl functional groups from the lysine residues of histones and non-histones. Among other things, histone lysine acetylation is highly…
HDAC (Histone deacetylases) are a class of enzymes that remove acetyl groups from an ε-N-acetyl lysine amino acid on a histone. To date, There are 18 human HDACs. Besides, HDACs…