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RLA-5331 is an Iron Activator Containing Anti-androgen

Louis Gilman February 27, 2023

Prostate cancer (PCa) is one of the most prevalent malignancies in the world. Depending on the grade of cancer, a variable percentage of these patients experience progression to castration-resistant prostate…

Castration Resistant Prostate Cancer Prostate Cancer

Xentuzumab is a Monoclonal Antibody That Targets IGF Ligands IGF1 and IGF2

Louis Gilman December 30, 2022

IGF, an insulin-like growth factor, regulates cell growth, proliferation, and survival. The IGF system is made up of IGF1, IGF2, insulin, and corresponding receptors. It transmits abnormal signals to cause…

Breast Cancer Castration Resistant Prostate Cancer Prostate Cancer

Proxalutamide (GT0918) is a Potent Androgen Receptor (AR) Antagonist

Louis Gilman July 7, 2021

Androgen receptors (ARs) mediate cell differentiation and development of prostate cancer. The target is a common therapeutic target in prostate cancer. Proxalutamide (GT0918) design is based on the core structure…

Castration Resistant Prostate Cancer Prostate Cancer

IPI-9119 is an Orally Active, Selective and Irreversible FASN Inhibitor

Louis Gilman September 2, 2020

Fatty acid synthase (FASN) is a multi-enzyme protein that catalyzes the synthesis of fatty acids. Its main function is to catalyze the synthesis of palmitate (C16:0) from acetyl CoA and…

Castration Resistant Prostate Cancer

Y06137 is a Selective BET Inhibitor for Treatment of CRPC

Louis Gilman April 25, 2019

Prostate cancer arises as an androgen driven disease. Therefore the mainstay of systemic therapy for patients with advanced disease is androgen deprivation therapy. Despite of significant responses, nearly all patients…

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Breast Cancer

BI 7446 is a STING Agonist for Immuno-oncology Research

Gastric Cancer Obesity

JNJ-38877605 is an Orally Active c-Met Inhibitor for Solid Tumour Research

Multiple Myeloma Myeloma

OATD-02 is an Orally Active Arginase 1/2 Inhibitor for Melanoma Research

autoimmune disease

INCB086550 is an Orally Active PD-L1 Inhibitor for Multiple Cancers Research

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