Month: October 2022

Zilovertamab is a Humanised Monoclonal ROR1 Antibody

Receptor tyrosine kinase-like orphan receptor 1 (ROR1) is an oncofetal protein present on many cancers. ROR1 reappears on hematological cancers and solid tumors, particularly those with high-grade histology. And ROR1 is a cell-surface protein that mediates signaling from its ligand. During embryogenesis, ROR1 has a physiological role in neural, auditory,...

RP-6685 is an Orally Active DNA Polθ Inhibitor

DNA polymerase theta (Polθ) is a unique, large (290 kDa) multifunctional A-family DNA polymerase that is required for DNA double-strand breaks (DSBs) repair through the microhomology-mediated end-joining (MMEJ) pathway. Importantly, MMEJ is intrinsically mutagenic, whereas break sites are often scarred with insertions and deletions. Besides, increasing evidence suggests that MMEJ is...

MPM-1, an Anticancer agent, is a Marine Eusynstyelamides Mimic

Autophagy  is the natural and conservative degradation of cells. Specifically, it can remove unnecessary or dysfunctional components through lysosomal-dependent regulation mechanisms. Besides, it allows the orderly degradation and recycling of cellular components. It eliminates molecular and subcellular elements through lysosomal-mediated degradation. This includes nucleic acids, proteins, lipids, and organelles...

GNE-9815 is a highly selective pan-RAF inhibitor, can be used to research KRAS mutant cancers

Rapidly accelerated fibrous sarcoma (RAF) kinases are a family of three serine/threonine-specific protein kinases associated with retroviral oncogenes. They play key roles in several cellular processes, including cell cycle progression, cell proliferation, cell metabolism, cell migration, cell differentiation, and apoptosis. Activation of RAF kinases requires interaction with RAS-GTPases. RAF...

Golcadomide is an Orally Active CRBN E3 Ligase Modulator (CELMoD)

Protein degradation agents based on the ubiquitin-proteasome pathway include a part of molecular glues. A molecular glue is a small molecule that stabilizes the interaction between two proteins that do not normally interact. If one of the proteins is ubiquitin ligase, molecular glue can cause another protein to undergo...

Parsatuzumab (RG 7414) is a Humanized mAb, Binding to EGFL7

Epidermal Growth Factor like domain 7 (EGFL7) is an endothelial cell-derived factor, mostly expressed in endothelial cells. EGFL7 takes part in the regulation of the spatial arrangement of cells during vascular tube assembly. The Egfl7 gene encodes active miR-126 which is related to cardiovascular diseases as well as the...