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Reliable, unbiased and up to date information in cancer research

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Reliable, unbiased and up to date information in cancer research

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Cancer

Alda-1 is a potent ALDH2 Agonist

Louis Gilman December 30, 2021

Aldehyde dehydrogenase 2 (ALDH2) is ubiquitously found in various tissues, including the heart, brain, and skeletal muscle, and highly expressed in the mitochondria. Many cellular functions show relations with ALDH2.…

Gastric Cancer Leukemia

ABT-737 is a Selective and BH3 Mimetic Bcl-2, Bcl-xL and Bcl-w Inhibitor

Louis Gilman December 28, 2021

Bcl-2 protein family is a key regulator of apoptosis and a marker of B-cell lymphoma. Importantly, apoptosis is an important physiological process of selective cell clearance, involving a variety of…

Lung Adenocarcinoma Lung Cancer Non-Small Cell Lung Cancer

Almonertinib is an Orally Active and Irreversible EGFR Inhibitor

Louis Gilman December 25, 2021

Lung cancer is one of the most common malignant tumors in the world. Its lethality ranks the first among many malignant tumors. In addition, the overexpression of the human ATP-binding…

Breast Cancer Endometrial Cancer Lymphoma Melanoma Non-Hodgkin Lymphoma Prostate Cancer Solid Tumors

Apitolisib is an Orally Active Class I PI3K and mTORC1/2 Inhibitor

Louis Gilman December 21, 2021

Activation of the pathway occurs following activating point mutations or amplification of the PIK3CA gene encoding the p110a PI3K isoform. Oncogenes such as PI3K, AKT, epidermal growth factor receptor (EGFR),…

Breast Cancer

MS4322 is a First-in-Class PRMT5 PROTAC Degrader

Louis Gilman December 20, 2021

PRMT5 is a member of type II protein arginine methyltransferases (PRMTs). When interacting with its binding partner MEP50, PRMT5 catalyzes monomethylation and symmetric dimethylation of arginine residues of its histone…

Cancer

Zebularine is a DNA Methyltransferase Inhibitor

Louis Gilman December 18, 2021

DNA methyltransferase (DNMT) family enzymes catalyze the transfer of methyl to DNA. Specifically, DNMT is a conserved cytosine methylase family, which plays a key role in epigenetic regulation. The DNMT…

Cancer

MRTX1133 is a Highly Selective, First-in-Class Inhibitor of KRAS G12D

Louis Gilman December 16, 2021

Mutant KRAS is an attractive drug target for the treatment of a number of cancers for many decades. Until recently, the high affinity of KRAS for GDP/GTP and the lack…

Glioblastoma Lung Cancer Non-Small Cell Lung Cancer

AZD1390 is a Highly Selective, Orally Active and Brain-Penetrant ATM Inhibitor

Louis Gilman December 15, 2021

Glioblastoma multiforme (GBM) is a lethal form of brain tumor arising from malignant glial cells. this disease affects 2 to 3 per 100,000 adults per year and accounts for 52%…

Colon Cancer Melanoma Renal Carcinoma

CBL0137 is an Histone Chaperone FACT Inhibitor

Louis Gilman December 11, 2021

Cancer harbors several characteristics, including high heterogeneity, diverse gene mutation, or rapid progression; consequently, treating cancer is difficult, and it easily relapses. Surgery, radiotherapy, chemotherapy, immunotherapy, and targeted therapy show…

Breast Cancer Cervical Cancer Lung Cancer

Trolox, an Analogue of Vitamin E, Possesses Antioxidant Effect

Louis Gilman December 9, 2021

Oxidative stress reflects the imbalance between the systemic performance of reactive oxygen species (ROS) and the ability of biological systems to easily detoxify active intermediates or repair the resulting damage.…

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Breast Cancer

BI 7446 is a STING Agonist for Immuno-oncology Research

Gastric Cancer Obesity

JNJ-38877605 is an Orally Active c-Met Inhibitor for Solid Tumour Research

Multiple Myeloma Myeloma

OATD-02 is an Orally Active Arginase 1/2 Inhibitor for Melanoma Research

autoimmune disease

INCB086550 is an Orally Active PD-L1 Inhibitor for Multiple Cancers Research

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