Urabrelimab (SRF231) is a Fully Human Anti-CD47 Monoclonal Antibody
CD47 (Cluster of Differentiation 47) is a transmembrane protein, belonging to the immunoglobulin superfamily. It can interact with signal-regulatory protein alpha (SIRPα) which is an inhibitory transmembrane receptor present on myeloid cells. The interaction leads to different cell-to-cell responses, such as phagocytosis inhibition, cell-cell fusion stimulation, and T-cell activation....
Coibamide A, an Cytotoxic Depsipeptide, Induces Autophagosome Accumulation
Autophagy is the key structure of macroautophagy. Macroautophagy is an intracellular degradation system of cytoplasmic contents. Meanwhile, autophagy is a new double-membrane vesicle formed during autophagy, which can phagocytose a variety of intracellular substances. It transports this autophagic material to the lysosome for subsequent degradation. The lysosomal hydrolase degrades...
Enavatuzumab (PDL192) is a Humanized IgG1 Monoclonal Antibody Targeting TWEAK
Antibody-dependent cytotoxicity (ADCC) is a cell-mediated immune defense mechanism. The effector cells of the immune system actively cleave target cells, and their membrane surface antigens are bound by specific antibodies. Besides, it is one of the mechanisms by which antibodies, as part of the humoral immune response, can limit...
Nanrilkefusp alfa is a Selective and Potent Agonist Fusion Protein of IL-15.
IL-15 is a cytokine involved in the regulation of the innate immune system. It stimulates the proliferation and activation of natural killer (NK) cells and memory CD8+ T cells. And also it promotes the secretion of a variety of cytokines. Moreover, IL-15 enhances the antibody-dependent cytotoxicity (ADCC) of antibodies. Specifically,...
Amivantamab (JNJ-61186372) is a Human EGFR-MET Bispecific Antibody
Epidermal growth factor (EGF) is a protein that stimulates cell proliferation, differentiation, and survival by binding to its receptor EGFR. Additionally, It exists in platelets, urine, saliva, milk, tears, and blood plasma. The mesenchymal-epithelial transition (MET) is the reverse process of the epithelial-mesenchymal transition (EMT). Moreover, MET involves morphological...
YL-939, a Potent Ferroptosis Inhibitor, Acts by Targeting the PHB2/Ferritin/Iron Axis
Ferroptosis is a form of programmed cell death mediated by iron-dependent lipid peroxidation and was first proposed by Brent Stockwell and Scott J. Dixon in 2012. It differs genetically and biochemically from other forms of regulated cell death, such as apoptosis, uncontrolled necrosis, and necrotizing apoptosis. The main features...
Bapotulimab (BAY-1905254) is an IgG2 Antibody Targeting ILDR2
Immunoglobulin-like domain containing receptor 2 (ILDR2) is a B7-like protein that belongs to the B7 family of immunomodulatory receptors. It can induce an immunosuppressive effect on T-cell responses. ILDR2 is a negative regulator for T cells. Besides, ILDR2 is expressed in immune cells and in immune-privileged and inflamed tissues....