Category: Acute Leukemia

Daunorubicin is a Topoisomerase II Inhibitor with potent Antineoplastic Activities

Topoisomerases are enzymes that regulate the overwinding or underwinding of DNA. The winding problem of DNA arises due to the intertwined nature of its double-helical structure. Topoisomerases are isomerase enzymes that act on the topology of DNA. Type I topoisomerase cuts one strand of a DNA double helix, relaxation...

MRT199665 is a ATP-Competitive MARK/SIK/AMPK Inhibitor

In acute myeloid leukemia (AML), chemotherapy resistance remains prevalent and poorly understood. AML are cancers of the blood. They originate in the hematopoietic progenitor cells as a result of the accumulation of genetic mutations that lead to cell transformation. Prevalence of mutations of genes encoding regulators of gene expression...

MM-589, a Cell-Permeable Inhibitor of WDR5-MLL Protein Protein Interaction

Acute leukemia is a kind of serious diseases, includes acute myeloid leukemia, acute lymphoblastic leukemia and blast crisis of chronic myelogenous leukemia. MLL1 (Mixed-lineage leukemia 1; KMT2A) is a histone methyltransferase, occurs in leukemia cells in a mutation form. MLL1 interacts with WD repeat domain 5 protein (WDR5), enhances...

BSc5371, an Irreversible FLT3 Inhibitor for Acute Leukemia Treatment

Acute leukemia is a kind of cancer diseases, severely affects people’s life. Acute myeloid leukemia (AML) is a malignant neoplasia. They fail to differentiate into functional blood cells, and continue proliferation. As a result, myeloblasts accumulate in the bone marrow. FLT3 (FMS-like tyrosine kinase 3) mutation plays an important...

CB-6644 is an Inhibitor of the RUVBL1/2 Complex

RUVBL1 and RUVBL2 are related ATPase associated with diverse cellular activities proteins. RUVBL2 is a human gene coding for a protein belonged to the diverse cellular activities family of proteins. RUVBL1 can form a hexamer with RUVBL2 protein. Both RUVBL1 and RUVBL2 can bind to nucleosomes. RUVBL1 and RUVBL2...

CF53, a Potent and Orally Active BET Inhibitor

Bromodomain and extra-terminal (BET) family is a well-known member of bromodomain family. Proteins of this family include BRD2, BRD3, BRD4 and a testis-specific protein, BRDT. BET proteins act as important epigenetic “readers” and play a vital role in regulating gene transcription. Thus, they are becoming hot targets for cancer...