Category: Acute Leukemia

MRT199665 is a ATP-Competitive MARK/SIK/AMPK Inhibitor

In acute myeloid leukemia (AML), chemotherapy resistance remains prevalent and poorly understood. AML are cancers of the blood. They originate in the hematopoietic progenitor cells as a result of the accumulation of genetic mutations that lead to cell transformation. Prevalence of mutations of genes encoding regulators of gene expression...

MM-589, a Cell-Permeable Inhibitor of WDR5-MLL Protein Protein Interaction

Acute leukemia is a kind of serious diseases, includes acute myeloid leukemia, acute lymphoblastic leukemia and blast crisis of chronic myelogenous leukemia. MLL1 (Mixed-lineage leukemia 1; KMT2A) is a histone methyltransferase, occurs in leukemia cells in a mutation form. MLL1 interacts with WD repeat domain 5 protein (WDR5), enhances...

BSc5371, an Irreversible FLT3 Inhibitor for Acute Leukemia Treatment

Acute leukemia is a kind of cancer diseases, severely affects people’s life. Acute myeloid leukemia (AML) is a malignant neoplasia. They fail to differentiate into functional blood cells, and continue proliferation. As a result, myeloblasts accumulate in the bone marrow. FLT3 (FMS-like tyrosine kinase 3) mutation plays an important...

CB-6644 is an Inhibitor of the RUVBL1/2 Complex

RUVBL1 and RUVBL2 are related ATPase associated with diverse cellular activities proteins. RUVBL2 is a human gene coding for a protein belonged to the diverse cellular activities family of proteins. RUVBL1 can form a hexamer with RUVBL2 protein. Both RUVBL1 and RUVBL2 can bind to nucleosomes. RUVBL1 and RUVBL2...

CF53, a Potent and Orally Active BET Inhibitor

Bromodomain and extra-terminal (BET) family is a well-known member of bromodomain family. Proteins of this family include BRD2, BRD3, BRD4 and a testis-specific protein, BRDT. BET proteins act as important epigenetic “readers” and play a vital role in regulating gene transcription. Thus, they are becoming hot targets for cancer...