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Network of Cancer Research

Reliable, unbiased and up to date information in cancer research

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Reliable, unbiased and up to date information in cancer research

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Cancer Colon Cancer Gastric Cancer

Tivantinib is a Selective c-Met Tyrosine Kinase Inhibitor

Louis Gilman April 30, 2022

c-Met (hepatocyte growth factor receptor, HGFR) is a type of receptor tyrosine kinase which belongs to the MET family.  c-Met exsists in the surfaces of various epithelial cells. Hepatocyte growth…

Acute Lymphoblastic Leukemia

Reversine is a ATP-Competitive Aurora Kinase Inhibitor

Louis Gilman April 28, 2022

Aurora kinases are serine/threonine kinases that play a prominent role in mitotic regulation. The Aurora A kinase, the “polar” kinase resides at spindle poles during mitosis. It is implicated in…

Cancer

Telatinib is an Orally Active Inhibitor of VEGFR2, VEGFR3, PDGFα, and c-Kit

Louis Gilman April 26, 2022

The importance of angiogenesis in solid tumor growth is well established. Inhibition of the vascular endothelial growth factor (VEGF)/VEGF receptor (VEGFR) pathway is now an approved and generally accepted treatment…

Cancer

Nimbolide Induces Apoptosis through Inactivation of NF-κB

Louis Gilman April 23, 2022

The transcription factor NF-κB is a nuclear factor that binds to the enhancer element of the immunoglobulin kappa light-chain of activated B cells. NF-κB exsists in nearly all cell types…

Pancreatic Ductal Adenocarcinoma

Ulixertinib is an Orally Active and ATP-Competitive ERK1/2 Inhibitor

Louis Gilman April 21, 2022

Effective treatment for pancreatic ductal adenocarcinoma (PDAC) is an urgent, unmet medical need. Targeting KRAS, the oncogene that is present in >95% of PDAC, is a heavily pursued strategy but…

Cancer

WAY 316606 is an Inhibitor of the Secreted Protein sFRP-1

Louis Gilman April 19, 2022

Human sFRP-1 is a 35 kD protein consisting of 313 amino acids. It containa 2 distinct structural domains, a netrin domain, and a cysteine-rich domain (CRD). The later domain is…

Bladder Cancer Cancer

Pirarubicin, an Anthracycline Antibiotics, Acts as a Topoisomerase II Inhibitor

Louis Gilman April 16, 2022

Pirarubicin has widely application in intravesical chemotherapy for bladder cancer, but drug resistance limits its efficacy; the mechanism still needs further exploration.   Bladder cancer is the most common malignancy…

Philadelphia-positive Leukemias

Bafetinib is a Lyn and Bcr-Abl Tyrosine Kinase Inhibitor

Louis Gilman April 14, 2022

The treatment of Philadelphia chromosome-positive (Ph+) leukemias has improved markedly. There are some inhibitors of Bcr-Abl tyrosine kinase (TK) that are effective for Ph<sup>+</sup> leukemias. However, resistance to imatinib can…

Breast Cancer

GNE-149 is an Orally Active Estrogen Receptor α Antagonist

Louis Gilman April 7, 2022

Estrogen receptor α (ERα) and β (ERβ) is a nuclear transcription factors involved in regulating many complex human physiological processes. Moreover, these proteins play a role in the nucleus and…

Pancreas Cancer

FH535 is a Potent Inhibitor of Wnt/β-catenin and PPAR

Louis Gilman April 3, 2022

The Wnt signaling pathway is important in normal development and in cancer. This signaling pathway is regulated by Wnt ligands, the APC-Axin complex and β-catenin. Wnt/β-catenin signaling pathway plays a…

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  • Panobinostat is a HDAC Inhibitor for Multiple Myeloma Research

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You Missed

Breast Cancer

BI 7446 is a STING Agonist for Immuno-oncology Research

Gastric Cancer Obesity

JNJ-38877605 is an Orally Active c-Met Inhibitor for Solid Tumour Research

Multiple Myeloma Myeloma

OATD-02 is an Orally Active Arginase 1/2 Inhibitor for Melanoma Research

autoimmune disease

INCB086550 is an Orally Active PD-L1 Inhibitor for Multiple Cancers Research

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