Pancreatic cancer is an extremely lethal disease with a poor prognosis. Traditional chemotherapeutic agent could improve the prognosis of the pancreatic cancer. For example, poly (ADP-ribose) polymerase (PARP) inhibitor (PARPi)…
EGFR (epidermal growth factor receptor) is a transmembrane protein and is a member of the ErbB family. Besides, EGFR is a protein tyrosine kinase expressed on many types of tumor…
Cancer and metabolism-related diseases have a significant impact on humans. Cancer cells are constitutively anabolic. It will cause quiescence and catabolism in normal cells because of they are unable to…
Uterine myomas and endometriosis are sex-hormone-dependent diseases. They affect up to 50-60% and 10-50% women of reproductive age, respectively. Endometriosis is an estrogen-dependent chronic inflammatory disease. The pathophysiology of this…
Cancer metastases have caused the major mortality rate for cancer patients, with limited options of treatment and unsatisfactory therapeutic efficacy. Estrogen and the estrogen receptors (ERs) are closely related to…