Category: Cancer Metastases

Linzagolix is a potent, non-Peptide, and Orally Active GnRH Antagonist

Uterine myomas and endometriosis are sex-hormone-dependent diseases. They affect up to 50-60% and 10-50% women of reproductive age, respectively. Endometriosis is an estrogen-dependent chronic inflammatory disease. The pathophysiology of this complex disease is multifactorial: in its pathogenesis, hormonal dysfunction, and proinflammatory microenvironment of eutopic and ectopic endometrium play a...

Erteberel is a Selective ERβ Agonist

Cancer metastases have caused the major mortality rate for cancer patients, with limited options of treatment and unsatisfactory therapeutic efficacy. Estrogen and the estrogen receptors (ERs) are closely related to breast cancer, ovarian cancer, colon cancer, prostate cancer, and endometrial cancer. Unlike the tumor-promoting role of estrogen receptor ERα,...