Cetuximab (C225) is an Anti-EGFR Monoclonal Antibody for Cancer Research
EGFR (epidermal growth factor receptor) is a transmembrane protein and is a member of the ErbB family. Besides, EGFR is a protein tyrosine kinase expressed on many types of tumor cells, including breast, ovarian, bladder, head and neck, and prostatic carcinoma. Mainly, In malignant tumors, EGFR overexpression is linked...
SH-BC-893 is an Orally Active Anti-neoplastic Sphingolipid Analog
Cancer and metabolism-related diseases have a significant impact on humans. Cancer cells are constitutively anabolic. It will cause quiescence and catabolism in normal cells because of they are unable to tolerate nutrient stress. So, oncogenic mutations will reselect the metabolic circuitry during the tumorigenic process to meet the increased...
Linzagolix is a potent, non-Peptide, and Orally Active GnRH Antagonist
Uterine myomas and endometriosis are sex-hormone-dependent diseases. They affect up to 50-60% and 10-50% women of reproductive age, respectively. Endometriosis is an estrogen-dependent chronic inflammatory disease. The pathophysiology of this complex disease is multifactorial: in its pathogenesis, hormonal dysfunction, and proinflammatory microenvironment of eutopic and ectopic endometrium play a...
Erteberel is a Selective ERβ Agonist
Cancer metastases have caused the major mortality rate for cancer patients, with limited options of treatment and unsatisfactory therapeutic efficacy. Estrogen and the estrogen receptors (ERs) are closely related to breast cancer, ovarian cancer, colon cancer, prostate cancer, and endometrial cancer. Unlike the tumor-promoting role of estrogen receptor ERα,...