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Reliable, unbiased and up to date information in cancer research

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Pancreas Cancer

IACS-15414 is an Orally Active SHP2 Inhibitor

Louis Gilman January 31, 2022

Src-homology-2-containing protein tyrosine phosphatase 2 (SHP2), encoded by the PTPN11 gene, is a classical nonreceptor protein tyrosine phosphatase (PTP). SHP2 is a ubiquitous protein tyrosine phosphatase with a relatively conserved…

Breast Cancer

ML-099 is a pan Ras-Related GTPases Activator

Louis Gilman January 29, 2022

To date, we identified 167 small GTPases in humans which are key signal transducing enzymes. Small GTPases comprise five main families whose eponymous members are Ras, Rho, Rab, ADP-ribosylation factor…

Cancer Neuroblastoma

Zingerone, an Orally Active Nontoxic Methoxyphenol, Possesses Anti-Inflammatory and Anti-Tumor Properties

Louis Gilman January 28, 2022

Humans have been using natural products for medicinal use for ages. Ginger (Zingiber officinale) is used as a condiment worldwide from times immemorial. Ginger has many health benefits in traditional…

Cancer

VU0359595 is a Selective PLD1 Inhibitor

Louis Gilman January 26, 2022

Phospholipase is a member of a very complex group of enzymes that break down phospholipids into fatty acids and other compounds. Phospholipase D (PLD) is an enzyme of the phospholipase…

Breast Cancer Ovary Cancer

SD-1029 is a JAK2/STAT3 Activation Inhibitor

Louis Gilman January 22, 2022

Janus kinase (JAK) is a family of intracellular, nonreceptor tyrosine kinases that transduce cytokine-mediated signals via the JAK-STAT pathway. JAK includes JAK1, JAK2, JAK3 and TYK2. JAK serves as the…

Chronic Lymphocytic Leukemia Leukemia Lymphoma Non-Hodgkin Lymphoma

Tirabrutinib is a Selective BTK Inhibitor

Louis Gilman January 18, 2022

The BTK kinases comprise 5 structural domains, including pleckstrin homology, TEC homology, Src homology, Src homology, and kinase domains. The activation of BTK kinase depends on recruitment to the plasma…

Head and Neck Cancer Melanoma Pancreas Cancer

β-Lapachone, a Naturally Occurring O-naphthoquinone, is a Topoisomerase I Inhibitor

Louis Gilman January 15, 2022

β-Lapachone is an ortho-naphthoquinone and inhibits topoisomerase I. β-Lapachone is a classic quinone-containing antitumor NQO1-bioactivatable drug that directly kills NQO1-overexpressing cancer cells. NQO1 is an antioxidative enzyme that helps recover…

Breast Cancer Lung Cancer Mesothelioma Non-Small Cell Lung Cancer Ovary Cancer Prostate Cancer

Rucaparib is a PARP Inhibitor

Louis Gilman January 13, 2022

PARP is a family of proteins involved in many cellular processes, such as DNA repair, genomic stability, and programmed cell death. At least 18 members of the PARP family are…

Acute Myeloid Leukemia Breast Cancer Colorectal Cancer

Dovitinib is a Multi-Targeted Tyrosine Kinase Inhibitor

Louis Gilman January 11, 2022

Tyrosine kinase is an enzyme that can transfer phosphate groups from ATP to tyrosine residues of specific proteins in cells. Specifically, this covalent post-translational modification is a key component of…

Cancer Colorectal Cancer Prostate Cancer

XL092 is a Potent Axl, Mer and C-Met kinase Inhibitor

Louis Gilman January 8, 2022

Human Axl belongs to the TAM subfamily of receptor tyrosine kinases that includes Mer. TAM kinases contain two immunoglobulin-like domains and two fibronectin type III domains. Many cancer cells exhibit…

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You Missed

B-cell malignancies

Parsaclisib is an Orally Active PI3Kδ Inhibitor for B-cell Malignancies Research

Leukemia

Nilotinib is an Orally Active Bcr-Abl Tyrosine Kinase Inhibitor for CML Research

Acute Lymphoblastic Leukemia Cancer Prostate Cancer

Temsirolimus is an mTOR Inhibitor for Kinds of Cancers Research

Cancer Nasopharyngeal Carcinoma

Toripalimab is an Anti-tumor PD-1 Antibody for Nasopharyngeal Carcinoma Research

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