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Reliable, unbiased and up to date information in cancer research

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Lymphoma

EEDi-5285 is an Orally Active Embryonic Ectoderm Development (EED) Inhibitor

Louis Gilman September 30, 2020

Polycomb protein EED is a member of the Polycomb-group (PcG) family. Specifically, the Polycomb group (PCG) is a class of proteins responsible for cell differentiation during development through transcriptional inhibition.…

Leukemia Lymphoma

Ilorasertib is an Orally Active ATP-Competitive Multitargeted Kinase Inhibitor

Louis Gilman September 29, 2020

Aurora kinases are key regulators of mitosis that overexpress in many cancer types. Ilorasertib (ABT-348) is a potent inhibitor of all three Aurora kinases, although it has greater activity versus…

Lymphoma

SJF620 is a Potent PROTAC BTK Degrader

Louis Gilman September 26, 2020

Bruton’s tyrosine kinase (BTK) is an enzyme encoded by the BTK gene in human. BTK is critical for the survival of B-cell neoplasms. BTK plays a crucial role in B…

Cancer

CMLD012073, an Amidino-Rocaglates, is a Potent eIF4A Inhibitor

Louis Gilman September 25, 2020

The eukaryotic translation initiation factors 4A (eIF4A) is crucial for the assembly of the translationally active ribosome. Especially, the eIF4A is an RNA helicase that forms part of the machinery…

Gliocytoma

RapaLink-1, a Third-Generation Bivalent mTOR Inhibitor, Combines Rapamycin with MLN0128

Louis Gilman September 23, 2020

Glioblastoma (GBM), the most common primary brain tumor, represents one of the most aggressive cancers. The signaling from PI3K and AKT to mTOR is commonly dysregulated in GBM. But, blockade…

Breast Cancer ER+ Breast Cancer HER2+ Breast Cancer

AZD-9833 is an Orally Active Estrogen Receptor (ER) Antagonist

Louis Gilman September 22, 2020

Estrogens participate in numerous physiological processes such as cell growth, reproduction, and differentiation. In females, the ovaries are the major site of estrogen synthesis producing the predominant estrogen 17b-estradiol (E2).…

Breast Cancer

SP-8356 is a Potent and Orally Active CD147 Inhibitor

Louis Gilman September 19, 2020

Breast cancer is one of the most fatal diseases in women and exhibits high incidence and mortality among various cancers. Among various signaling pathways that promote tumor growth and progression,…

Liver Cancer

PU02 is an Allosteric Antagonist of 5-HT3 Receptor

Louis Gilman September 17, 2020

Cancer is a usual disease and a leading cause of death in the world. Therefore, developing new agents specifically targeting cancer cells has achieved more and more researches. As it…

Myeloma

SC99 is an Orally Active and Selective STAT3 Inhibitor

Louis Gilman September 16, 2020

STAT3 is a member of the STAT protein family. STAT3 mediates the expression of a variety of genes in response to cell stimulation. So it plays a key role in…

Breast Cancer

MPT0G211 is an Orally Active and Selective HDAC6 Inhibitor

Louis Gilman September 15, 2020

Alzheimer’s disease (AD) is one of the most common neurodegenerative diseases, accounting for more than 80% of dementia cases worldwide. AD leads to the progressive loss of mental capacity and…

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Recent Posts

  • BI 7446 is a STING Agonist for Immuno-oncology Research
  • JNJ-38877605 is an Orally Active c-Met Inhibitor for Solid Tumour Research
  • OATD-02 is an Orally Active Arginase 1/2 Inhibitor for Melanoma Research
  • INCB086550 is an Orally Active PD-L1 Inhibitor for Multiple Cancers Research
  • Panobinostat is a HDAC Inhibitor for Multiple Myeloma Research

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You Missed

Breast Cancer

BI 7446 is a STING Agonist for Immuno-oncology Research

Gastric Cancer Obesity

JNJ-38877605 is an Orally Active c-Met Inhibitor for Solid Tumour Research

Multiple Myeloma Myeloma

OATD-02 is an Orally Active Arginase 1/2 Inhibitor for Melanoma Research

autoimmune disease

INCB086550 is an Orally Active PD-L1 Inhibitor for Multiple Cancers Research

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