Apoptosis is a cellular process critical to the normal development and homeostasis of multicellular organisms. Therefore, dysfunction of the apoptosis machinery has been linked to many human diseases. These diseases…
Hepatocyte growth factor (HGF) is an effective angiogenesis peptide. Specifically, it is produced by stromal cells and mesenchymal cells. It stimulates epithelial cell proliferation, movement, morphogenesis, and angiogenesis in various…
β-Lapachone is an ortho-naphthoquinone and inhibits topoisomerase I. β-Lapachone is a classic quinone-containing antitumor NQO1-bioactivatable drug that directly kills NQO1-overexpressing cancer cells. NQO1 is an antioxidative enzyme that helps recover…
PERK (Protein kinase R (PKR)-like endoplasmic reticulum kinase) is a type I endoplasmic reticulum transmembrane protein. Generally, PERK contains a stress-sensing domain facing the endoplasmic reticulum lumen and a cytosolic…
TP53 (p53) is the single most frequently altered gene in human cancers, with mutations being present in approximately 50% of all invasive tumors. Besides, p53 is mutated in at least…