Protein arginine methylation, a common post-translational modification, involves in numerous cellular processes including transcription, DNA repair, mRNA splicing and signal transduction. Protein arginine methyltransferases (PRMTs) catalyze arginine methylation on both chromatin-bound and cytoplasmic proteins. Currently, there are nine protein arginine methyltransferases (PRMTs) encoded in mammalian genomes. Each PRMT isoform...