B7-H3 (CD276) is a T cell co-stimulator and co-suppressor molecule. Specifically, B7-H3 plays an important role in tumor cell apoptosis, proliferation, adhesion, angiogenesis, invasion, migration, and escape from immune surveillance.…
Autophagy is the natural and conservative degradation of cells. Specifically, it can remove unnecessary or dysfunctional components through lysosomal-dependent regulation mechanisms. Besides, it allows the orderly degradation and recycling of…
Photodynamic therapy (PDT), a phototherapy, is a minimally invasive therapeutic procedure. PDT consists of three essential components-photosensitizer, light and oxygen. None of these is individually toxic, but together they initiate…
There are numerous growth factors involved in tumor angiogenesis, but foremost among them is the family of vascular endothelial growth factors (VEGFs). The VEGF family includes VEGFA, VEGFB, VEGFC, VEGFD,…
NUT midline carcinoma (NMC) is a rare, aggressive subtype of squamous carcinoma. This kind of cancer is usually driven by BRD4-NUT fusion oncoprotein. BRD4, a BET protein, binds to chromatin…