MPM-1, an Anticancer agent, is a Marine Eusynstyelamides Mimic
Autophagy is the natural and conservative degradation of cells. Specifically, it can remove unnecessary or dysfunctional components through lysosomal-dependent regulation mechanisms. Besides, it allows the orderly degradation and recycling of cellular components. It eliminates molecular and subcellular elements through lysosomal-mediated degradation. This includes nucleic acids, proteins, lipids, and organelles...
Temoporfin is a Second‐generation Photosensitizer for Cancer
Photodynamic therapy (PDT), a phototherapy, is a minimally invasive therapeutic procedure. PDT consists of three essential components-photosensitizer, light and oxygen. None of these is individually toxic, but together they initiate a photochemical reaction that culminates in the generation of a highly-reactive product termed singlet oxygen. Singlet oxygen can rapidly...
Motesanib is a potent ATP-Competitive Inhibitor of VEGFR1/2/3
There are numerous growth factors involved in tumor angiogenesis, but foremost among them is the family of vascular endothelial growth factors (VEGFs). The VEGF family includes VEGFA, VEGFB, VEGFC, VEGFD, and placenta growth factor (PGF). These ligands bind with different affinities to three endothelial receptor tyrosine kinases (RTKs), such...
NEO2734 is an Orally Active Dual p300/CBP and BET Bromodomain Selective Inhibitor
NUT midline carcinoma (NMC) is a rare, aggressive subtype of squamous carcinoma. This kind of cancer is usually driven by BRD4-NUT fusion oncoprotein. BRD4, a BET protein, binds to chromatin through its two bromodomains. At the same time, NUT recruits the p300 HAT to activate oncogenic target genes transcription....