Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal neoplasms of the gastrointestinal tract. While the application of targeted tyrosine kinase inhibitors has revolutionized the treatment of gastrointestinal stromal tumors (GISTs). The targeted tyrosine kinase inhibitors inhibit KIT-driven proliferation, diverse mutations to this kinase drive resistance to established therapies....