Category: Oral Carcinoma

Embelin is a Nonpeptidic XIAP Inhibitor

Embelin is an inhibitor of X-linked inhibitor of apoptosis protein (XIAP). It derives from the fruit of Embelia ribes. Embelin also possess therapeutic properties, such as anticancer, antioxidant, anti-inflammation, antidiabetes, and antihelminthic qualities.   XIAP is the most potent member of the inhibitors of apoptosis proteins (IAP) gene family....

EC0489, a SMDC for Cancer Therapy

Small molecule drug conjugates (SMDCs) contain three parts: a targeting ligand, a linker, and a drug payload. SMDCs have their own strengths such as manageable synthesis and a non-immunogenic nature. The molecular weights of SMDCs are potentially much lower and lead to good cell penetration in tumors and better...