Embelin is a Nonpeptidic XIAP Inhibitor
Embelin is an inhibitor of X-linked inhibitor of apoptosis protein (XIAP). It derives from the fruit of Embelia ribes. Embelin also possess therapeutic properties, such as anticancer, antioxidant, anti-inflammation, antidiabetes, and antihelminthic qualities. XIAP is the most potent member of the inhibitors of apoptosis proteins (IAP) gene family....
GNA002, a Specific EZH2 Inhibitor, Suppresses H3K27Me3 and Effectively Reactivates PRC2-Silenced Tumor Suppressor Genes
Enhancer of zeste homolog 2 (EZH2) is a critical oncogene. Meanwhile, it is a promising drug target in human malignant tumors. H3K27Me3 functions as a suppressive marker of gene transcription. Previous studies have revealed that EZH2 are largely due to its ability to suppress the expression of a cohort...
EC0489, a SMDC for Cancer Therapy
Small molecule drug conjugates (SMDCs) contain three parts: a targeting ligand, a linker, and a drug payload. SMDCs have their own strengths such as manageable synthesis and a non-immunogenic nature. The molecular weights of SMDCs are potentially much lower and lead to good cell penetration in tumors and better...