Nuclear factor (erythroid-derived 2)-like 2 (NRF2) is a master regulator of the cellular antioxidant response. It is genetically activated in Non-Small Cell Lung Cancers (NSCLCs) by, for instance, mutations in…
The transcription factor ONECUT2 (OC2) is a master regulator of androgen receptor networks in mCRPC (metastatic castration-resistant prostate cancer ). OC2 acts as a survival factor in mCRPC models. OC2…
BMI-1 is a highly conserved class II member of the Polycomb group of genes, regulating diverse aspects of transcription, stem cell maintenance, cell proliferation, and oncogenesis. BMI-1 has vital functions…
Malignant melanoma represents the most aggressive and deadliest form of cutaneous cancer. This disease possesses the characteristic of increasing incidence, high metastasis, rapid disease progression, poor prognosis, and high mortality.…
A study from Victoria K Woodcock suggested that AZD0424 is an inhibitor of the proto-oncogenic non-receptor tyrosine kinases Src and ABL1. The kinase plays an indefensible role in cancer. Src…
BET (Bromodomain and extra terminal domain) is a well-known member of the bromodomain family. It contains BRD2, BRD3, BRD4, and BRDT, which have two tandem bromodomains (BD1 and BD2). BD1…
PIN1 is a prolyl isomerase, which binds to several proteins, acts as a post phosphorylation control and regulates protein function. PIN1 targets proteins containing phosphorylated S/T-P sites firstly via the…
Phospholipase D (PLD) belongs to the phospholipase superfamily, which widely exists in animals, plants, yeast, bacteria, and viruses. In mammalian cells, there are two PLD isoforms, PLD1 and PLD2. The…
HDACs are important targets for cancer therapy. Histone deacetylase (HDAC) inhibitors are a promising class of drugs for the treatment of cancers, especially subcutaneous T-cell lymphoma. In this study, Han-Lin…
During multistep development, cancer cells acquire different biological capabilities such as sustaining proliferative signaling, activating invasion and metastasis. Activation of oncogenes, atypical changes in metabolism, and loss of p53 function…