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Network of Cancer Research

Reliable, unbiased and up to date information in cancer research

Network of Cancer Research

Reliable, unbiased and up to date information in cancer research

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Non-Small Cell Lung Cancer

BPK-29, a NR0B1 Ligand, Disrupts Protein Interactions for NR0B1-WT

Louis Gilman September 29, 2019

Nuclear factor (erythroid-derived 2)-like 2 (NRF2) is a master regulator of the cellular antioxidant response. It is genetically activated in Non-Small Cell Lung Cancers (NSCLCs) by, for instance, mutations in…

Prostate Cancer

CSRM617 is a Transcription Factor ONECUT2 Inhibitor for Prostate Cancer

Louis Gilman September 28, 2019

The transcription factor ONECUT2 (OC2) is a master regulator of androgen receptor networks in mCRPC (metastatic castration-resistant prostate cancer ). OC2 acts as a survival factor in mCRPC models. OC2…

Acute Myeloid Leukemia

PTC596 is an Orally Active and Selective BMI-1 Inhibitor

Louis Gilman September 27, 2019

BMI-1 is a highly conserved class II member of the Polycomb group of genes, regulating diverse aspects of transcription, stem cell maintenance, cell proliferation, and oncogenesis. BMI-1 has vital functions…

Melanoma

SS-208 is a Selective HDAC6 Inhibitor for Melanoma

Louis Gilman September 26, 2019

Malignant melanoma represents the most aggressive and deadliest form of cutaneous cancer. This disease possesses the characteristic of increasing incidence, high metastasis, rapid disease progression, poor prognosis, and high mortality.…

Solid Tumors

AZD0424 is an Orally Active and Dual Selective Src/Abl Kinase Inhibitor

Louis Gilman September 25, 2019

A study from Victoria K Woodcock suggested that AZD0424 is an inhibitor of the proto-oncogenic non-receptor tyrosine kinases Src and ABL1. The kinase plays an indefensible role in cancer. Src…

Leukemia

BY27 is a Selective and Orally Active BET BD2 Inhibitor

Louis Gilman September 24, 2019

BET (Bromodomain and extra terminal domain) is a well-known member of the bromodomain family. It contains BRD2, BRD3, BRD4, and BRDT, which have two tandem bromodomains (BD1 and BD2). BD1…

Breast Cancer

KPT-6566 is a Selective PIN1 Inhibitor

Louis Gilman September 23, 2019

PIN1 is a prolyl isomerase, which binds to several proteins, acts as a post phosphorylation control and regulates protein function. PIN1 targets proteins containing phosphorylated S/T-P sites firstly via the…

Breast Cancer

VU0155069, a Selective PLD1 Inhibitor, Blocks Tumor Cell Invasion

Louis Gilman September 22, 2019

Phospholipase D (PLD) belongs to the phospholipase superfamily, which widely exists in animals, plants, yeast, bacteria, and viruses. In mammalian cells, there are two PLD isoforms, PLD1 and PLD2. The…

Lymphoma

MPT0E028, an Orally Active HDAC Inhibitor, Induces Apoptosis by Targeting HDAC and Akt

Louis Gilman September 20, 2019

HDACs are important targets for cancer therapy. Histone deacetylase (HDAC) inhibitors are a promising class of drugs for the treatment of cancers, especially subcutaneous T-cell lymphoma. In this study, Han-Lin…

Cancer

DVD-445 is a TrxR1 Inhibitor for Cancer Therapy

Louis Gilman September 19, 2019

During multistep development, cancer cells acquire different biological capabilities such as sustaining proliferative signaling, activating invasion and metastasis. Activation of oncogenes, atypical changes in metabolism, and loss of p53 function…

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  • Panobinostat is a HDAC Inhibitor for Multiple Myeloma Research

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You Missed

Breast Cancer

BI 7446 is a STING Agonist for Immuno-oncology Research

Gastric Cancer Obesity

JNJ-38877605 is an Orally Active c-Met Inhibitor for Solid Tumour Research

Multiple Myeloma Myeloma

OATD-02 is an Orally Active Arginase 1/2 Inhibitor for Melanoma Research

autoimmune disease

INCB086550 is an Orally Active PD-L1 Inhibitor for Multiple Cancers Research

Network of Cancer Research

Reliable, unbiased and up to date information in cancer research

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