Members of the Ras and Rho family of GTPases are signal transducers that regulate many biological processes, including cell cycle progression, cell survival, and cell differentiation. When persistently activated, GTPases…
Glioblastoma multiforme is the most prevalent and aggressive form of primary brain cancer. Glioblastoma multiforme is the most hostile type of brain cancer. Its aggressiveness is due to increased invasion,…
The spindle assembly checkpoint (SAC) is important for cell survival. Its inactivation generates lethal genomic instability in cancer cells. Inhibition of SAC signaling through targeting of Mps1 has provided an…
The fluoropyrimidine 5-fluorouracil (5-FU) is an antimetabolite drug that is widely used for the treatment of cancer, particularly for colorectal cancer. Fluorouracil is part of a group of chemotherapy drugs…
Sirtuins are evolutionarily conserved epigenetic proteins involved in diverse cellular processes in both prokaryotes and eukaryotes. Among them, Sirtuin 6 (SIRT6) is a member of the sirtuin family of NAD+-dependent…
Recently, the specific and nongenetic IAP-dependent protein eraser (SNIPER) is a novel approach to the treatment of various diseases, including cancer. SNIPER composes of two different ligands connected by a…
The phosphoinositide 3-kinase (PI3K) pathway has key roles in regulating physiologic functions, including cellular proliferation, growth, metabolism, and survival. The PI3K pathway frequently activats in cancer cells, via several mechanisms,…
A proteolysis targeting chimera (PROTAC) is a two-headed molecule capable of removing specific unwanted proteins. Rather than acting as a conventional enzyme inhibitor, a PROTAC works by inducing selective intracellular…
The glucocorticoid receptor (GR) is a nuclear receptor, with the synonym of NR3C1. The receptor exhibits almost all cells of the body, regulates genes. And the latter ones control the…
Hairy and enhancer of split homolog-1 (HES1) is a part of an extensive family of basic helix-loop-helix (bHLH) proteins. It plays a crucial role in the control and regulation of…