Category: Chemotherapy

FPDT is an anti-glioblastoma agent and shows anti-glioblastoma activity by AKT pathway.

FPDT (2-(4-fluorophenyloamino)-5-(2,4-dihydroxyphenyl)-1,3,4-thiadiazole) is an anti-glioblastoma agent. FPDT displays cytotoxic with IC50 values of 44-68 μM for GBM cells and >100 μM for human astrocytes HA. Besides, Anti-glioblastoma activity of FPDT is linked to downregulation of the AKT pathway. FPDT (0-100 µM; 48 h) shows anti-proliferative activity with IC50 values of 53.53, 44.98, 55.20, 56.37, 67.73, >100...

Fasentin, a Chemical Sensitizer, Inhibits GLUT-1 and GLUT-4 Transporters

Angiogenesis forms new blood vessels from pre-existing ones. Angiogenesis is a physiological and transient process that in adults is limited to some processes. They include reproductive cycles, wound healing, and bone repair. Nevertheless, a persistent and deregulated angiogenesis takes place in cancer and other diseases, such as proliferative retinopathies,...