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Network of Cancer Research

Reliable, unbiased and up to date information in cancer research

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Reliable, unbiased and up to date information in cancer research

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Melanoma Pancreas Cancer

CX-5461 is an Orally Active rRNA Synthesis Inhibitor

Louis Gilman October 30, 2021

RNA polymerase is an enzyme that synthesizes RNA from a DNA template. Specifically, RNA synthesis or transcription is the process of transcribing DNA nucleotide sequence information into RNA sequence information.…

Cancer

SB 258719 is a Selective 5-HT7 Receptor Antagonist

Louis Gilman October 28, 2021

The neurotransmitter 5-hydroxytryptamine (5-HT) has an array of pharmacological and physiological roles within the central nervous system. It has the potential to develop a number of useful medicines. The selective…

Lung Cancer Non-Small Cell Lung Cancer

Brusatol (NSC 172924) is a Nrf2 Inhibitor

Louis Gilman October 26, 2021

Keap1-Nrf2 is the major regulator of cytoprotective responses to electrophilic chemicals or reactive oxygen species (ROS).  Upregulation of Nrf2 inducing by inactivation of Keap1 is often observed in cancer cells.…

Acute Myeloid Leukemia

Quizartinib (AC220) is an Orally Active and Highly Selective FLT3 Tyrosine Kinase Inhibitor

Louis Gilman October 24, 2021

Receptor tyrosine kinase FMS like tyrosine kinase 3 (FLT3) is a member of the class III receptor tyrosine kinase family. The family also includes FMS, kit, and platelet-derived growth factor…

Bladder Cancer Prostate Cancer

Saracatinib (AZD0530) is a potent Src Family Inhibitor

Louis Gilman October 21, 2021

Src is a prototypical non-receptor tyrosine kinase. It also includes c-Yes and Fyn. Src transduces signals that control processes involved in cell proliferation, adhesion, and motility. Clinical evidence supports a…

Leukemia

Cytochalasin B is a Mycotoxin binding to the Barbed end of Actin Filaments

Louis Gilman October 19, 2021

Actin, a family of globular multi-functional proteins, is the most abundant protein in most eukaryotic cells. It forms microfilaments in the cytoskeleton, and the thin filaments in muscle fibrils. Actin…

Leukemia

Atuveciclib is a Highly Selective and Orally Active PTEFb, CDK9 Inhibitor

Louis Gilman October 16, 2021

Positive transcription elongation factor P-TEFb is a kinase composed of CDK9 and cyclin T. Specifically, P-TEFb plays an important role in the transcriptional regulation of RNA polymerase II (pol II)…

Breast Cancer Colorectal Cancer Hematological Malignancies Lung Cancer Non-Small Cell Lung Cancer Pancreas Cancer Small Cell Lung Cancer

Ganetespib (STA-9090) is a HSP90 Inhibitor

Louis Gilman October 14, 2021

Hsp90 is a molecular chaperone that regulates the posttranslational folding, stability, and function of its protein substrates (client proteins), many of which play critical roles in cell growth, differentiation, and…

Acute Myeloid Leukemia Lung Cancer Melanoma Non-Small Cell Lung Cancer Prostate Cancer

Elesclomol (STA-4783) is an Oxidative Stress Inducer and Induces Apoptosis

Louis Gilman October 13, 2021

Modulating reactive oxygen species (ROS) levels has been proposed as a therapeutic strategy for cancer. In normal cells, ROS are produced at low concentrations and cancer cells produce elevated levels…

Breast Cancer

Sapanisertib is an Orally Active and ATP-Dependent mTOR Inhibitor

Louis Gilman October 12, 2021

Acute myelogenous leukemia (AML) is a heterogeneous disease. It often relapses after standard chemotherapy or proves refractory to available treatments. Therefore, It needs novel therapies for AML. In AML, many…

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  • Panobinostat is a HDAC Inhibitor for Multiple Myeloma Research

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You Missed

Breast Cancer

BI 7446 is a STING Agonist for Immuno-oncology Research

Gastric Cancer Obesity

JNJ-38877605 is an Orally Active c-Met Inhibitor for Solid Tumour Research

Multiple Myeloma Myeloma

OATD-02 is an Orally Active Arginase 1/2 Inhibitor for Melanoma Research

autoimmune disease

INCB086550 is an Orally Active PD-L1 Inhibitor for Multiple Cancers Research

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