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GN25 is a Specific p53-Snail Binding Inhibitor with Antitumor Effects

P53, also known as Tumor protein P53, or transformation-related protein 53 (TRP53) is a regulatory protein that is often mutated in human cancers. Besides, p53 is the strongest tumor suppressor gene. In addition, p53 also induces cell death, and growth arrest and suppresses metastasis in response to various kinds...

Etrolizumab is a Gut-selective, Anti-β7 Integrin McAb

Integrin β7 is an integrin protein that in humans is encoded by the ITGB7 gene. Besides, It can pair with ITGA4 (CD49d) to form the heterodimeric integrin receptor α4β7, or with ITGAE (CD103) to form αEβ7. α4β7 integrin plays a crucial role in leucocyte homing to the intestinal mucosa...

DC-S239 is a Selective SET7 Inhibitor With Anti-Cancer Activity

SET7 is a protein lysine methyltransferase (PKMT), which methylates a plethora of proteins and regulates diverse biological processes. Meanwhile, SET7 plays a significant role in transcriptional regulation, cell cycle control, differentiation, DNA repair, and DNMT1 stability. Specifically, researches show that SET7 is closely associated with various diseases. Particularly, SET7...

Gardiquimod is a TLR7/8 Agonist and Could Inhibit HIV-1 Infection

Toll-like receptors (TLR) are a family of highly conserved pattern recognition receptors. They participate in innate immune responses to pathogen infection. Some of the more than two dozen members of this class of receptors that include TLR3, TLR7, TLR8, and TLR9 are localized within intracellular vesicles including the endoplasmic...

Namodenoson (CF-102) is a Selective A3 Adenosine Receptor (A3AR) Agonist

The adenosine A3 receptor (A3AR) comes from the cloning from rat, sheep and human sources. In vitro stimulation of this adenosine receptor subtype shows it inhibits adenylyl cyclase. It also stimulates phospholipase C and inositol-1,4,5-triphosphate (IP3) will form. In vivo activation of the A3 receptor, it also mediates heart...

Splitomicin is a cell-permeable, potent SIR2 Inhibitor

The class III histone deacetylases (HDAC) are also known as the sirtuins. They are a member of the sirtuin family of proteins (SIRT1~7) and homologs of Sir2 (Sir2p) in yeast. SIRT1 shares a domain of about 275 amino acids with other sirtuins. It uses NAD+ to mediate the deacetylation...