Poly (ADP-ribose) polymerases (PARPs) are a family of related enzymes that share the ability to catalyze the transfer of ADP-ribose to target proteins. The PARP family comprises 17 members. They…
IL-15 is an inflammatory cytokine, as well as an activator of T cells and natural killer (NK) cells. It binds to and signals in a complex consisting of the IL-2/IL-15 receptor…
BRD9 is a subunit of the human BAF (SWI/SNF) nucleosome remodeling complex. Besides, BRD9 contains a bromodomain and is closely related to BRD7. Importantly, The BRD9 gene is frequently present…
JAK (Janus kinase) is a family of intracellular, non-receptor tyrosine kinases that transduce cytokine-mediated signals via the JAK-STAT pathway. Particularly, JAK2 is a member of the JAK family of cytoplasmic…
Iron is an essential nutrient required for DNA synthesis, energy production, and normal cellular growth. Meanwhile, Iron circulates in the plasma bound to transferrin (Tf). Particularly, Most cells express Tf…
P53, also known as Tumor protein P53, or transformation-related protein 53 (TRP53) is a regulatory protein that is often mutated in human cancers. Besides, p53 is the strongest tumor suppressor…
Integrin β7 is an integrin protein that in humans is encoded by the ITGB7 gene. Besides, It can pair with ITGA4 (CD49d) to form the heterodimeric integrin receptor α4β7, or…
SET7 is a protein lysine methyltransferase (PKMT), which methylates a plethora of proteins and regulates diverse biological processes. Meanwhile, SET7 plays a significant role in transcriptional regulation, cell cycle control,…
The adenosine A3 receptor (A3AR) comes from the cloning from rat, sheep and human sources. In vitro stimulation of this adenosine receptor subtype shows it inhibits adenylyl cyclase. It also…
The class III histone deacetylases (HDAC) are also known as the sirtuins. They are a member of the sirtuin family of proteins (SIRT1~7) and homologs of Sir2 (Sir2p) in yeast.…