dBRD9 is a PROTAC and can Selective Degrades BRD9
BRD9 is a subunit of the human BAF (SWI/SNF) nucleosome remodeling complex. Besides, BRD9 contains a bromodomain and is closely related to BRD7. Importantly, The BRD9 gene is frequently present in variable copy numbers in lung cancer and has emerged as an attractive therapeutic target in cancer. Moreover, the...
Ruxolitinib (INCB018424) is a Selective JAK1/2 Inhibitor for Cancer Research
JAK (Janus kinase) is a family of intracellular, non-receptor tyrosine kinases that transduce cytokine-mediated signals via the JAK-STAT pathway. Particularly, JAK2 is a member of the JAK family of cytoplasmic tyrosine kinases, which also include JAK1, JAK3, and TYK2. Importantly, the study shows that JAK1 and JAK2 may interact,...
SG-094 is a Potent TPC2 Inhibitor for HCC Reasearch
TPC2 inhibitor, SG-094 can inhibit hepatocellular carcinoma (HCC) tumor growth by inhibiting two-pore channel 2 (TPC2). TPCs are eukaryotic intracellular voltage-gated and ligand-gated cation-selective ion channels. TPCs are an ancient family of ion channels. SG-094 exists in the membranes of acidic organelles such as endosomes and lysosomes. These organelles...
Ferristatin (NSC306711) is a Potent Iron Transport Inhibitor and Promotes Transferrin Receptor Degradation
Iron is an essential nutrient required for DNA synthesis, energy production, and normal cellular growth. Meanwhile, Iron circulates in the plasma bound to transferrin (Tf). Particularly, Most cells express Tf receptors on their surface to bind and internalize Tf by receptor-mediated endocytosis. Importantly, Study shows that alterations in the...
FA16 is a Specific Ferroptosis Inducer with Metabolic Stability
Ferroptosis is an iron-dependent form of regulatory cell death (RCD). Ferroptosis is an oxidative cell death distinct from apoptosis, driven by intense lipid peroxidation. System Xc–-GSH-GPX4 is the main ferroptosis inhibition pathway. Among them, system System Xc– is a cystine/glutamic acid antitransporter. It is responsible for the introduction of...
GN25 is a Specific p53-Snail Binding Inhibitor with Antitumor Effects
P53, also known as Tumor protein P53, or transformation-related protein 53 (TRP53) is a regulatory protein that is often mutated in human cancers. Besides, p53 is the strongest tumor suppressor gene. In addition, p53 also induces cell death, and growth arrest and suppresses metastasis in response to various kinds...
Etrolizumab is a Gut-selective, Anti-β7 Integrin McAb for Inflammatory Bowel Disease (IBD) Research
Integrin β7 is an integrin protein that in humans is encoded by the ITGB7 gene. Besides, It can pair with ITGA4 (CD49d) to form the heterodimeric integrin receptor α4β7, or with ITGAE (CD103) to form αEβ7. α4β7 integrin plays a crucial role in leucocyte homing to the intestinal mucosa...