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Network of Cancer Research

Reliable, unbiased and up to date information in cancer research

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Reliable, unbiased and up to date information in cancer research

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Trilaciclib is an Orally Active CDK4 and CDK6 Inhibitor

Louis Gilman May 29, 2021

The cell cycle is a highly conserved process. Additionally, this process must maintain genomic integrity and replicative capacity for proper cell maintenance and proliferation. The cell cycle consists of four…

Lymphoma Multiple Myeloma

Lenalidomide, a Ligand of CRBN, is an Orally Active Immunomodulator

Louis Gilman May 28, 2021

Immunomodulatory imide drugs (IMiDs) are a class of immunomodulatory drugs containing an imide group. The discovery of anti-angiogenic and anti-inflammatory properties promoted the development of Thalidomide analogs. These compounds bind…

Cancer

PHT-7.3 is a Selective Inhibitor of Connector Enhancer of Kinase Suppressor of Ras 1 (Cnk1)

Louis Gilman May 27, 2021

Cnksr1 (Cnk1) is a multidomain scaffold protein important for cell proliferation, survival, and migration. Cnk1 can act as a scaffold for a number of Ras and Rho GTPase family members,…

Prostate Cancer

FTI-277 is a Farnesyl Transferase (FTase) Inhibitor

Louis Gilman May 26, 2021

Farnesyl transferase (FTase) is a zinc-dependent enzyme. It adds a 15-carbon isoprenoid called a farnesyl group to proteins bearing a CaaX motif. FTase regulates the activation of oncogenic Ras protein…

Glioma Lung Cancer Pancreas Cancer Prostate Cancer

Lonafarnib is an Orally Active FPTase Inhibitor

Louis Gilman May 22, 2021

Farnesyl transferase (FTase) is a zinc-dependent enzyme, which coordinates a zinc cation on its β subunit at the lip of the active site. FTase has two subunits: a 48kDa α-subunit…

Lung Adenocarcinoma Lung Cancer Non-Small Cell Lung Cancer

DT-061 is an Orally Active PP2A Activator

Louis Gilman May 21, 2021

Protein phosphatase 2A (PP2A) comprises a family of serine/threonine phosphatases, minimally containing a well-conserved catalytic subunit. PP2A plays a prominent role in the regulation of specific signal transduction cascades. Additionally,…

Cancer

GSK973 is a Highly Selective BET BD2 Inhibitor

Louis Gilman May 19, 2021

The bromodomain and extra-terminal (BET) family of proteins are epigenetic readers of chromatin. The two tandem bromodomains (BD1 and BD2) of each of the four proteins (BRD2, 3, 4, and…

Cancer

BI-3406 is an Orally Active and Selective KRAS and SOS1 Interaction Inhibitor

Louis Gilman May 18, 2021

KRAS functions as a molecular switch, cycling between inactive (GDP-bound) and active (GTP-bound) states to transduce extracellular signals via cell-surface receptors. KRAS signaling occurs through engagement with effector proteins that…

Breast Cancer Lymphoma

MD-222 is a First-in-Class Highly Potent PROTAC Degrader of MDM2

Louis Gilman May 14, 2021

PROTACs are heterobifunctional molecules that connect a POI ligand to an E3 ubiquitin ligase recruiting ligand with an optimal linker. Researchers reported the discovery of MD-222. MD-222 is the first-in-class…

Gastric Cancer

SIS3 is a Potent and Selective Inhibitor of Smad3 Phosphorylation

Louis Gilman May 13, 2021

Smad contains a series of proteins with similar structures, which are the main signal transducer in transforming growth factors β (TGF-b) superfamily. Specifically, they play an important role in the…

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Breast Cancer

BI 7446 is a STING Agonist for Immuno-oncology Research

Gastric Cancer Obesity

JNJ-38877605 is an Orally Active c-Met Inhibitor for Solid Tumour Research

Multiple Myeloma Myeloma

OATD-02 is an Orally Active Arginase 1/2 Inhibitor for Melanoma Research

autoimmune disease

INCB086550 is an Orally Active PD-L1 Inhibitor for Multiple Cancers Research

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