Category: Breast Cancer

Ganetespib (STA-9090) is a HSP90 Inhibitor

Hsp90 is a molecular chaperone that regulates the posttranslational folding, stability, and function of its protein substrates (client proteins), many of which play critical roles in cell growth, differentiation, and survival. The Hsp90 machinery serves as a biochemical buffer for a number of oncogenic signaling proteins causally implicated in...

Sapanisertib is an Orally Active and ATP-Dependent mTOR Inhibitor

Acute myelogenous leukemia (AML) is a heterogeneous disease. It often relapses after standard chemotherapy or proves refractory to available treatments. Therefore, It needs novel therapies for AML. In AML, many signaling pathways are abnormally activated and lead to uncontrolled proliferation/survival of immature myeloid progenitors. The 50% to 80% of...

Wortmannin (SL-2052) is an Orally Active, Selective and Irreversible PI3K Inhibitor

Phosphoinositide 3-kinases (PI3Ks), also called phosphatidylinositol 3-kinases, are a family of enzymes involved in cellular functions. Class I PI3K enzymes consist of four distinct catalytic isoforms, PI3Kα, PI3Kβ, PI3Kδ and PI3Kγ. There are three major classes of PI3K enzymes, being class IA widely associated to cancer. Class IA PI3K,...

Sorafenib (Bay 43-9006) is an Orally Active Raf Inhibitor

The Raf family consists of three members: A-Raf, B-Raf, and Raf-1. Ras/RAF/MEK extracellular signal-regulated kinase (ERK) pathway is relevant to the control of many basic cellular processes, including proliferation, survival, and differentiation. Specifically, Raf-1 and B-Raf can form heterodimers, which may be important for cell transformation. RAF protein is...

HS-131 is a near Infrared Dye Tethered Hsp90 Inhibitor

Hsp90 (heat shock protein 90) is a molecular chaperone protein. Specifically, Hsp90 can help other proteins fold correctly, stabilize proteins, resist heat stress, and contribute to protein degradation. It can also stabilize many proteins needed for tumor growth. Besides, Hsp90 is present in all branches of bacteria and eukaryotes....