Category: Breast Cancer

STX-0119 is a Selective, Orally Active STAT3 Dimerization Inhibitor

STAT3 protein is a potential cytoplasmic transcription factor. Constitutive activation of signal transducer and activator of transcription 3 (STAT3) is related to the proliferation, survival, invasion, and angiogenesis of many human cancer cells. Specifically, it transmits signals of cytokines and growth factors from the cell membrane to the nucleus...

MPM-1, an Anticancer agent, is a Marine Eusynstyelamides Mimic

Autophagy  is the natural and conservative degradation of cells. Specifically, it can remove unnecessary or dysfunctional components through lysosomal-dependent regulation mechanisms. Besides, it allows the orderly degradation and recycling of cellular components. It eliminates molecular and subcellular elements through lysosomal-mediated degradation. This includes nucleic acids, proteins, lipids, and organelles...

Simmiparib is An Orally Active PARP1/2 Inhibitor

Poly (ADP-ribose) polymerase (PARP), a family of proteins, is involved in various cellular processes such as DNA repair and programmed cell death. PARP is present in the cell nucleus. It consists of a DNA-binding domain, a caspase-cleaved domain, an auto-modification domain, and a catalytic domain. In particular, the protein...

AZD-9574 is a potent and brain penetrant PARP1 inhibitor

The Poly (ADP-ribose) polymerase (PARP) family has numerous essential functions. PARP plays roles in cellular processes such as transcription, chromatin remodeling, DNA damage response, and repair. DNA double-strand breaks (DSBs) are the most deleterious form of DNA damage. Besides, DSBs can be repaired by homologous recombination repair (HRR) or...

ARV-471 is an Estrogen Receptor PROTAC Degrader for Breast Cancer

PROTAC is a heterobifunctional molecule containing two small molecule binding moieties. Specifically, PROTACs in cells seek and selectively bind to target proteins. PROTAC then recruits specific E3 ligases to the target protein. Besides, it forms a ternary complex in close proximity to the target protein and E3 ligase. In...

PU-H54, a Grp94-selective Inhibitor, Can be Used for Breast Cancer Research

Heat shock proteins (HSPs) are a family of proteins produced by cells in response to exposure to stress conditions. Besides, HSPs are a large class of molecular chaperones. It plays a role in protein maturation, refolding, and degradation. Moreover, HSPs may promote or inhibit neural development by regulating cell...

Lapatinib is a Potent Inhibitor of the ErbB-2 and EGFR Tyrosine Kinase Domains

Growth factors and their transmembrane receptor tyrosine kinase play important roles in cell proliferation, survival, migration, and differentiation. Additionally, Epidermal growth factor (EGF)-like proteins stimulates cells to divide by activating members of the EGF receptor (EGFR) family. Many types of human tumor cells growth and development are related to the...