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Rucaparib is an Orally Active PARP Inhibitor for Prostate Cancer Research

Louis Gilman August 25, 2023

Ovarian cancer (OC) is the eighth most common neoplasia in women, and the fifth leading cause of cancer-related deaths. Due to a lack of early stage detection, about 70% of…

Cancer Ovary Cancer

PHY34 is an ATP6V0A2/CAS Inhibitor for Ovarian Cancer Research

Louis Gilman August 18, 2023

Autophagy (autophagocytosis) is the natural, conserved degradation of the cell. It removes unnecessary or dysfunctional components through a lysosome-dependent regulated mechanism. It allows the orderly degradation and recycling of cellular…

Ovary Cancer

Niraparib (MK-4827) is an Orally Active PARP1/PARP2 Inhibitor for Cancer Research

Louis Gilman May 23, 2023

Poly (ADP-ribose) polymerases (PARPs) are a family of related enzymes that share the ability to catalyze the transfer of ADP-ribose to target proteins. There are at least 18 members of…

Cancer Ovary Cancer

Adavosertib (AZD-1775) is a Potent Wee1 Inhibitor for Colon Cancer Research

Louis Gilman May 8, 2023

The regulation of cell size is critical to ensure the functionality of a cell. Besides environmental factors such as nutrients, growth factors and functional load, cell size is also controlled…

Cancer Ovary Cancer

SU056, a YB-1 Inhibitor, Induces Cell-cycle Arrest, Apoptosis and Inhibits Cell Migration in Cancer

Louis Gilman March 9, 2023

Y-box-binding proteins (YB proteins) belong to a family of proteins that contain a cold shock domain. The YB protein consists of three members, YB-1, YB-2 and YB-3. Among the YB…

Chemotherapy Ovary Cancer

Zilovertamab is a Humanised Monoclonal ROR1 Antibody

Louis Gilman October 29, 2022

Receptor tyrosine kinase-like orphan receptor 1 (ROR1) is an oncofetal protein present on many cancers. ROR1 reappears on hematological cancers and solid tumors, particularly those with high-grade histology. And ROR1 is…

Breast Cancer Ovary Cancer

SD-1029 is a JAK2/STAT3 Activation Inhibitor

Louis Gilman January 22, 2022

Janus kinase (JAK) is a family of intracellular, nonreceptor tyrosine kinases that transduce cytokine-mediated signals via the JAK-STAT pathway. JAK includes JAK1, JAK2, JAK3 and TYK2. JAK serves as the…

Breast Cancer Lung Cancer Mesothelioma Non-Small Cell Lung Cancer Ovary Cancer Prostate Cancer

Rucaparib is a PARP Inhibitor

Louis Gilman January 13, 2022

PARP is a family of proteins involved in many cellular processes, such as DNA repair, genomic stability, and programmed cell death. At least 18 members of the PARP family are…

Colorectal Cancer Melanoma Ovary Cancer

Birinapant (TL32711), a Bivalent Smac Mimetic, is an Antagonist for XIAP and cIAP1

Louis Gilman September 22, 2021

XIAP is a protein that prevents apoptosis. XIAP is a member of apoptosis protein family (IAP) inhibitors. Specifically, IAP blocks cell death in vitro and in vivo by inhibiting different…

Colorectal Cancer Lung Cancer Non-Small Cell Lung Cancer Ovary Cancer Pancreas Cancer

Rineterkib is an Orally Active RAF and ERK1/2 Inhibitor

Louis Gilman April 1, 2021

ERK1 and ERK2 are related protein-serine/threonine kinases that participate in the Ras-Raf-MEK-ERK signal transduction cascade. This cascade participates in the regulation of a large variety of processes. It includes cell…

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Breast Cancer

BI 7446 is a STING Agonist for Immuno-oncology Research

Gastric Cancer Obesity

JNJ-38877605 is an Orally Active c-Met Inhibitor for Solid Tumour Research

Multiple Myeloma Myeloma

OATD-02 is an Orally Active Arginase 1/2 Inhibitor for Melanoma Research

autoimmune disease

INCB086550 is an Orally Active PD-L1 Inhibitor for Multiple Cancers Research

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