Rucaparib is an Orally Active PARP Inhibitor for Prostate Cancer Research
Ovarian cancer (OC) is the eighth most common neoplasia in women, and the fifth leading cause of cancer-related deaths. Due to a lack of early stage detection, about 70% of…
Ovarian cancer (OC) is the eighth most common neoplasia in women, and the fifth leading cause of cancer-related deaths. Due to a lack of early stage detection, about 70% of…
Autophagy (autophagocytosis) is the natural, conserved degradation of the cell. It removes unnecessary or dysfunctional components through a lysosome-dependent regulated mechanism. It allows the orderly degradation and recycling of cellular…
Poly (ADP-ribose) polymerases (PARPs) are a family of related enzymes that share the ability to catalyze the transfer of ADP-ribose to target proteins. There are at least 18 members of…
The regulation of cell size is critical to ensure the functionality of a cell. Besides environmental factors such as nutrients, growth factors and functional load, cell size is also controlled…
Y-box-binding proteins (YB proteins) belong to a family of proteins that contain a cold shock domain. The YB protein consists of three members, YB-1, YB-2 and YB-3. Among the YB…
Receptor tyrosine kinase-like orphan receptor 1 (ROR1) is an oncofetal protein present on many cancers. ROR1 reappears on hematological cancers and solid tumors, particularly those with high-grade histology. And ROR1 is…
Janus kinase (JAK) is a family of intracellular, nonreceptor tyrosine kinases that transduce cytokine-mediated signals via the JAK-STAT pathway. JAK includes JAK1, JAK2, JAK3 and TYK2. JAK serves as the…
PARP is a family of proteins involved in many cellular processes, such as DNA repair, genomic stability, and programmed cell death. At least 18 members of the PARP family are…
XIAP is a protein that prevents apoptosis. XIAP is a member of apoptosis protein family (IAP) inhibitors. Specifically, IAP blocks cell death in vitro and in vivo by inhibiting different…
ERK1 and ERK2 are related protein-serine/threonine kinases that participate in the Ras-Raf-MEK-ERK signal transduction cascade. This cascade participates in the regulation of a large variety of processes. It includes cell…