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Reliable, unbiased and up to date information in cancer research

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Reliable, unbiased and up to date information in cancer research

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Colorectal Cancer

ML-00253764 is a Brain Penetrant Melanocortin Receptor 4 Antagonist

Louis Gilman April 29, 2021

The involuntary weight loss that occurs as some diseases poses a serious medical problem. For example, sarcopenia, cancer cachexia, rheumatoid arthritis, and hip fractures can lead to involuntary weight loss.…

Leukemia Megakaryoblastic Leukemia

AZD1208 is an Orally Bioavailable and Highly Selective PIM Kinases Inhibitor

Louis Gilman April 28, 2021

Pim kinases, also known as serine/threonine kinases, have three highly homologous isoforms namely Pim-1, Pim-2, and Pim-3. And Pim-1, Pim-2, and Pim-3 are recurrent proviral integration locus in Moloney murine…

Acute Myeloid Leukemia

SB-332235 is an Orally Active CXCR2 Antagonist

Louis Gilman April 27, 2021

Chemokines are low m.w. proteins that modulate the immune response through the chemoattraction and activation of leukocytes. These mediators have four classes. Chemokines in which the first two cysteines are…

Breast Cancer Triple-Negative Breast Cancer

LYN-1604 is a Potent ULK1 Activator

Louis Gilman April 24, 2021

UNC-51 like kinase 1 (ULK1) is the mammalian homolog of ATG1. ULK1 is an autophagic initiator that may decide the subsequent cell fate. In the autophagic process, ULK1 is a component…

Cancer

MS049 is a Selective and Dual Inhibitor of PRMT4 and PRMT6

Louis Gilman April 22, 2021

Protein arginine N-methyltransferase 4 (PRMT4) methylation of arginine residues in proteins plays a key role in transcriptional regulation. Specifically, PRMT4 binds to transcription activators called p160 and CBP/P300. Besides, the…

Cancer

L-Moses Disrupts PCAF-Brd Histone H3.3 Interaction

Louis Gilman April 21, 2021

Bromodomains proteins (Brds) bind to acetylated lysines (KAc) through the Brd acetyllysine-binding site. Misregulation of these proteins is linked to the onset and progression of multiple disease states. They include…

Endometrial Adenocarcinoma Endometrial Cancer

Miransertib is an Orally Active, Selective and Allosteric Akt Inhibitor

Louis Gilman April 20, 2021

The AGC kinases AKT1, AKT2, and AKT3 are key mediators of the PI3K/AKT/mTOR signaling pathway. Additionally, AKT promotes diverse physiological processes, including cell proliferation, migration, and protein synthesis, et al.…

Chronic Myeloid Leukemia Leukemia

Dasatinib is an Orally Active Dual Bcr-Abl and Src Family Tyrosine Kinase Inhibitor

Louis Gilman April 17, 2021

Src is an important member of the non-receptor protein tyrosine kinase. Furthermore, Src plays a key role in the regulation of many cells through the extracellular ligand binding to the…

Cancer

APS-2-79 is a KSR-Dependent Antagonist of RAF-Mediated MEK Phosphorylation

Louis Gilman April 15, 2021

Deregulation of the Ras-MAPK pathway is an early event in many different cancers and a key driver of resistance to targeted therapies. Kinase suppressor of Ras (KSR) is a MAPK…

Cancer

Retro-2 is a Selective Inhibitor of Retrograde Protein Trafficking

Louis Gilman April 14, 2021

Viruses critically depend on host cellular factors to establish a productive infection. Retro-2 is an inhibitor of endosome-to-Golgi retrograde transport of the plant toxin ricin and bacterial Shiga toxin. However,…

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Recent Posts

  • Erlotinib is an EGFR TKI for NSCLC and Pancreatic Cancer Research
  • Parsaclisib is an Orally Active PI3Kδ Inhibitor for B-cell Malignancies Research
  • Nilotinib is an Orally Active Bcr-Abl Tyrosine Kinase Inhibitor for CML Research
  • Temsirolimus is an mTOR Inhibitor for Kinds of Cancers Research
  • Toripalimab is an Anti-tumor PD-1 Antibody for Nasopharyngeal Carcinoma Research

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You Missed

NSCLC Pancreatic cancer

Erlotinib is an EGFR TKI for NSCLC and Pancreatic Cancer Research

B-cell malignancies

Parsaclisib is an Orally Active PI3Kδ Inhibitor for B-cell Malignancies Research

Leukemia

Nilotinib is an Orally Active Bcr-Abl Tyrosine Kinase Inhibitor for CML Research

Acute Lymphoblastic Leukemia Cancer Prostate Cancer

Temsirolimus is an mTOR Inhibitor for Kinds of Cancers Research

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