The bromodomain is a protein domain of about 110 amino acids, which can recognize acetylated lysine residues. Specifically, the bet (Bromo- and terminal domain) family consists of germ cell-specific (BRDT)…
C-met is a protein encoded by a met gene in humans, which has tyrosine kinase activity. Specifically, Met is an essential one-way tyrosine kinase receptor for embryonic development, organogenesis, and…
Breast cancer is the leading cause of cancer mortality among women in Korea, England, and the United States of America. Invasion and metastasis are the most lethal characteristics of breast…
LIM-kinase (Limk) is a serine-threonine protein kinase. Two isoforms are LIM kinase 1 (Limk1) and LIM kinase 2 (Limk2). Limk1 is overexpressed in cancerous prostate cells and tissues. Previous studies…
Hec1 (Ndc80) is one of the outer kinetochore proteins and forms heterotetramers with proteins NUF2, SPC25, and SPC24. Specifically, drugs that interfere with mitosis are part of the most successful…
PRDM9 is a zinc finger protein that binds DNA at specific locations in the genome and alleles influence human chromosomal rearrangements, causing hereditary diseases. MRK-740 is a potent selective and…
Rpn13 is a known component of the proteasome. Especially, Rpn13 binds ubiquitin-like domains of the UBL/UBA family of ubiquitin receptors. Rpn13, as an ubiquitin receptor, offers a docking position for…
Many aspects of genome regulation and metabolism require histone acetylation. Accordingly, dysfunctional histone acetylation has been implicated in numerous diseases, including cancer. Histone acetyltransferases (HATs) and histone deacetylases (HDACs) regulate…
Signal transducer and activator of transcription 3 (STAT3) is involved in the regulation of early embryonic development, angiogenesis, immune response, cell proliferation, and apoptosis. Additionally, STAT3 overexpresses in many cancers.…
Lysine-specific demethylase 1 (LSD1) is a human protein encoded by the kdm1a gene. Specifically, LSD1 is a flavin-dependent monoamine oxidase that demethylates monomethyl and dimethyllysine, especially H3K4 and H3K9. Besides,…