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Reliable, unbiased and up to date information in cancer research

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Pancreas Cancer

Troglitazone is an Orally Active PPARγ Agonist

Louis Gilman November 30, 2021

Pancreatic cancer is the fourth leading cause of cancer-related deaths in Japan. Gemcitabine has been the standard therapy for advanced pancreatic cancer for over a decade. Additional novel combination therapies…

Breast Cancer

Fadrozole is a Potent, Selective and Nonsteroidal Aromatase Inhibitor

Louis Gilman November 27, 2021

Aromatase occurs widely in tissues such as adipose tissue, brain, testes, and ovaries. It is a membrane-bound microsomal complex containing NADPH-cytochrome c reductase and cytochrome P-450 units. In this article,…

Colorectal Cancer Kidney Cancer

Axitinib is a Multi-Targeted Tyrosine Kinase Inhibitor

Louis Gilman November 26, 2021

Vascular endothelial growth factor (VEGF) is an important signal protein. Importantly, it is involved in angiogenesis and angiogenesis (blood vessels grow from a pre-existing vascular system). All members of VEGF…

Cancer Colon Cancer

A 83-01 is a Potent Inhibitor of TGF-β Type I Receptor ALK5 Kinase

Louis Gilman November 23, 2021

TGF-β, activin, nodal, and bone morphogenetic proteins (BMPs) belong to the TGF-β superfamily. It regulates a wide range of cellular responses, including cell proliferation, differentiation, adhesion, migration, and apoptosis. TGF-β…

Lymphoma T-cell Lymphoma

PR-104A is a Hypoxia-Selective DNA Cross-Linking Agent and Cytotoxin

Louis Gilman November 23, 2021

PR-104, like TH-302, is a prodrug of nitrogen mustard that has shown some degree of efficacy in adult patients with relapsed/refractory acute myeloid leukemia (AML). PR-104A (SN 27858) is the…

Cancer

Oltipraz is a Nrf2 Inhibitor

Louis Gilman November 18, 2021

Multidrug resistance-associated proteins (Mrps) are ATP-dependent transporters involved in the efflux of a vast number of endogenous and exogenous chemicals. GSH is one of the liver's main defenses against oxidative…

Medulloblastoma Pancreas Cancer

Cyclopamine is a Hedgehog (Hh) Pathway Antagonist

Louis Gilman November 17, 2021

Hedgehog (Hh) signal pathway is a signal pathway that transmits information to embryonic cells for appropriate cell differentiation. Specifically, Hedgehog signaling pathway is one of the key regulators of animal…

Gastric Cancer

Crizotinib is an Orally Active, ATP-Competitive ALK and c-Met inhibitor

Louis Gilman November 13, 2021

In this article, we will introduce an orally bioavailable, ATP-competitive ALK and c-Met inhibitor, Crizotinib. The IC50 values for ALK and c-Met kinases are 20 and 8 nM, respectively. Additionally, in cell-based assays, Crizotinib…

Prostate Cancer

Anisomycin, a Protein Synthesis Inhibitor, also Interferes DNA Synthesis

Louis Gilman November 11, 2021

Protein synthesis is a core biological process, which balances the loss of cellular proteins by producing new proteins. Specifically, proteins perform many key functions as enzymes, structural proteins, or hormones.…

Breast Cancer

IMD-0354 is a Selective IKKβ Inhibitor

Louis Gilman November 9, 2021

IKKβ is an enzyme that is part of an intracellular signaling pathway activated by cytokines involved in triggering an immune response. Particularly, Phosphorylated IκB degrades and releases NF-κB through the…

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You Missed

Breast Cancer

BI 7446 is a STING Agonist for Immuno-oncology Research

Gastric Cancer Obesity

JNJ-38877605 is an Orally Active c-Met Inhibitor for Solid Tumour Research

Multiple Myeloma Myeloma

OATD-02 is an Orally Active Arginase 1/2 Inhibitor for Melanoma Research

autoimmune disease

INCB086550 is an Orally Active PD-L1 Inhibitor for Multiple Cancers Research

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