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Network of Cancer Research

Reliable, unbiased and up to date information in cancer research

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Reliable, unbiased and up to date information in cancer research

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Pancreas Cancer

ZZW-115, a NUPR1 Inhibitor, Possesses Anticancer Activity via Inducing Necroptosis and Apoptosis

Louis Gilman August 29, 2020

NUPR1 is an intrinsically disordered protein (IDP) with an entirely disordered conformation. It binds to DNA in a manner similar to other chromatin proteins to control the expression of gene…

Melanoma

BRD9500 is an Orally Active Phosphodiesterases 3 (PDE3) Inhibitor with Antitumor Activity

Louis Gilman August 27, 2020

Phosphodiesterase 3 (PDE3) is one member of the PDE family and has two subtypes, PDE3A and PDE3B. PDE3A mainly expresses in heart, platelet, vascular smooth muscle, and oocytes and is…

Cancer

YKL-5-124 is a Selective, Irreversible and Covalent CDK7 Inhibitor

Louis Gilman August 26, 2020

Cyclin-dependent kinase 7 (CDK7) is a member of the cyclin-dependent protein kinase (CDK) family. Specifically, CDK7 is an important component of TFIIH, which is involved in transcription initiation and DNA…

Cancer

JH295 is an Irreversible and Selective NIMA-Related Kinase 2 (Nek2) Inhibitor

Louis Gilman August 25, 2020

NIMA-related kinase 2 (Nek2) is a homodimeric serine/threonine kinase. It localizes to centrosomes, the microtubule organizing centers of the cell. At the onset of mitosis, Nek2 phosphorylates the inter-centrosome linker…

Lung Adenocarcinoma Lung Cancer

BM-1197 is a Potent and Selective Dual Bcl-2/Bcl-xL Inhibitor

Louis Gilman August 22, 2020

Bcl-2 and Bcl-xL are critical regulators of apoptosis. The pharmacological inhibition of Bcl-2 and Bcl-xL represents a promising strategy for cancer treatment. In addition, BM-1197 is a potent and efficacious…

Breast Cancer

SBP-0636457, a SMAC Mimetic, is an IAP Antagonist

Louis Gilman August 20, 2020

Cancer cells regularly acquire resistance to programmed cell death, or apoptosis, which not only supports cancer progression but also leads to resistance to therapeutic agents. In this study, researchers focus…

Breast Cancer Triple-Negative Breast Cancer

SP-146 is a Selective and non-ATP-Competitive Aurora B Inhibitor

Louis Gilman August 19, 2020

Aurora B Kinase is a serine-threonine kinase and plays an important role in mitosis. This kinase also plays an important role in mitosis as a serine-threonine kinase. It also a…

Cancer

ATH686 is a Selective and ATP-Competitive FLT3 Inhibitor

Louis Gilman August 18, 2020

FLT3 is a kind of cytokine receptor, belonging to class III tyrosine kinase. Specifically, FLT3 signaling is important for the normal development of hematopoietic stem cells and progenitor cells. Specifically,…

Cholangiocarcinoma

SC-43 is a Potent and Orally Active SHP-1 Agonist and STAT3 Phosphorylation Inhibitor

Louis Gilman August 15, 2020

Cholangiocarcinoma (CCA) is the second most common hepatic malignancy after hepatocellular carcinoma (HCC). CCAs are epithelial malignancies that arise from cholangiocytes and are aggressive behavior and advanced clinical stage. STAT3…

Acute Myeloid Leukemia

SKI-178 is a Potent SphK1 and SphK2 Inhibitor

Louis Gilman August 13, 2020

Sphingosine kinase (SphK) is an oncogenic lipid kinase and a key regulator of the sphingolipid metabolic pathway. The SphK isoforms (SphK1 and SphK2) catalyze the conversion of the pro-apoptotic substrate…

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Recent Posts

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You Missed

NSCLC Pancreatic cancer

Erlotinib is an EGFR TKI for NSCLC and Pancreatic Cancer Research

B-cell malignancies

Parsaclisib is an Orally Active PI3Kδ Inhibitor for B-cell Malignancies Research

Leukemia

Nilotinib is an Orally Active Bcr-Abl Tyrosine Kinase Inhibitor for CML Research

Acute Lymphoblastic Leukemia Cancer Prostate Cancer

Temsirolimus is an mTOR Inhibitor for Kinds of Cancers Research

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