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Reliable, unbiased and up to date information in cancer research

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Ibrutinib is a Btk Inhibitor for Autoimmune Disease and B-cell Malignancy Research

Louis Gilman July 17, 2023

Bruton tyrosine kinase (Btk), a non-receptor kinase, is a member of the Tec family kinases. Btk is exists in B cells and myeloid cells. Btk has a carboxy-terminal catalytic domain…

Lymphoma Mantle Cell Lymphoma

BSJ-03-204 is a Selective Palbociclib-Based CDK4/6 Dual Degrader (PROTAC)

Louis Gilman October 28, 2020

The chimeric proteolytic enzyme (PROTAC) is a heterobifunctional small molecule. Specifically, it is composed of two active domains and an adaptor that can remove specific proteins that are not needed.…

Lymphoma Mantle Cell Lymphoma

GSK778 is a Potent and Selective Inhibitor of BET BD1

Louis Gilman July 30, 2020

The bromodomain is a protein domain of about 110 amino acids, which can recognize acetylated lysine residues. Specifically, the bet (Bromo- and terminal domain) family consists of germ cell-specific (BRDT)…

Mantle Cell Lymphoma

PRN1008 is a Reversible Covalent and Oral Active Inhibitor of Bruton’s Tyrosine Kinase (BTK)

Louis Gilman April 18, 2019

Bruton’s tyrosine kinase (BTK) is a nonreceptor tyrosine kinase in human encoded by BTK gene. Besides, the kinase belongs to the TEC protein tyrosine kinase family of kinases. Additionally, this…

Recent Posts

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  • OATD-02 is an Orally Active Arginase 1/2 Inhibitor for Melanoma Research
  • INCB086550 is an Orally Active PD-L1 Inhibitor for Multiple Cancers Research
  • Panobinostat is a HDAC Inhibitor for Multiple Myeloma Research

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You Missed

Breast Cancer

BI 7446 is a STING Agonist for Immuno-oncology Research

Gastric Cancer Obesity

JNJ-38877605 is an Orally Active c-Met Inhibitor for Solid Tumour Research

Multiple Myeloma Myeloma

OATD-02 is an Orally Active Arginase 1/2 Inhibitor for Melanoma Research

autoimmune disease

INCB086550 is an Orally Active PD-L1 Inhibitor for Multiple Cancers Research

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