Inbakicept is an IL-15 Superagonist for Cancer Research
IL-15 is an inflammatory cytokine, as well as an activator of T cells and natural killer (NK) cells. It binds to and signals in a complex consisting of the IL-2/IL-15 receptor…
Abexinostat is an Orally Available Pan-HDAC Inhibitor
HDAC (Histone deacetylases) are a class of enzymes that remove acetyl groups from an ε-N-acetyl lysine amino acid on a histone. To date, There are 18 human HDACs. Besides, HDACs…
Golcadomide is an Orally Active CRBN E3 Ligase Modulator (CELMoD)
Protein degradation agents based on the ubiquitin-proteasome pathway include a part of molecular glues. A molecular glue is a small molecule that stabilizes the interaction between two proteins that do…
Tirabrutinib is a Selective BTK Inhibitor
The BTK kinases comprise 5 structural domains, including pleckstrin homology, TEC homology, Src homology, Src homology, and kinase domains. The activation of BTK kinase depends on recruitment to the plasma…
Apitolisib is an Orally Active Class I PI3K and mTORC1/2 Inhibitor
Activation of the pathway occurs following activating point mutations or amplification of the PIK3CA gene encoding the p110a PI3K isoform. Oncogenes such as PI3K, AKT, epidermal growth factor receptor (EGFR),…
CJ-2360 is a Potent and Orally Active ALK Inhibitor
Anaplastic lymphoma kinase (ALK) is a receptor tyrosine kinase belonging to the insulin receptor (IR) kinase superfamily. It highly expresses in adult brain tissue and exerts an important role in…
BI-3802-Induced Polymerization Triggers Degradation of BCL6
PROTAC has been developed to degrade a wide range of clinically relevant targets. These small-molecule degraders engage both the E3 ligase and the target protein to promote the formation of…