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Glioblastoma Multiforme Gliocytoma

GW2974 is an EGFR/HER2 Inhibitor for Glioblastoma Multiforme Research

Louis Gilman September 21, 2023

The human EGF receptor (HER) 2 receptor tyrosine kinase is a survival factor for human cardiomyocytes. It plays an essential role in cardiac development during embryogenesis. Here, we will introduce…

Breast Cancer Glioblastoma Gliocytoma

Olinvacimab (TTAC-0001) is a Human Anti-VEGFR2 mAb for Cancer Research

Louis Gilman April 4, 2023

Olinvacimab (TTAC-0001) is a fully human anti-VEGFR2 monoclonal antibody from a fully human naive single-chain variable fragment phage library. Olinvacimab (TTAC-0001) inhibits VEGF and binds to KDR with a Kd…

Cancer Glioblastoma Glioblastoma Multiforme Gliocytoma Myelodysplastic Syndrome Myelodysplastic Syndrome

Asunercept (APG101) is a Selective CD95L Inhibitor for Glioblastoma Research

Louis Gilman February 16, 2023

Glioblastoma is the most frequent and aggressive form of brain tumour. Significantly, the highly invasive growth of these tumors often prevents complete surgical resection. Consequently, patients progress shortly after surgery.…

Glioblastoma Glioblastoma Multiforme Gliocytoma

Efineptakin alfa (NT-17) is a Long-Acting Recombinant Human IL-7 for Glioblastoma Research

Louis Gilman February 7, 2023

In this article, we will introduce a long-acting recombinant human IL-7, Efineptakin alfa. Efineptakin alfa is a potent T-cell amplifier, with a homodimeric IL-7 fused to the hybridizing IgD/IgG4 immunoglobulin…

Colon Cancer Colorectal Cancer Glioblastoma Gliocytoma

AZ31 is a Highly Selective and Orally Active ATM Inhibitor

Louis Gilman October 13, 2022

Ataxia telangiectasia mutated (ATM) is an ATP-dependent phosphatidylinositol 3-kinase-related kinase (PIKK) serine/threonine protein kinase. ATM is related to ATR, DNA-PKcs, mTOR, SMG1 and the non-enzymatic TRRAP within this enzyme family.…

Gliocytoma Glioma

CP681301 is a Potent CDK5 Inhibitor

Louis Gilman September 26, 2022

CDKs (Cyclin-dependent kinases) are serine-threonine kinases first discovered for their role in regulating the cell cycle. They are also involved in regulating transcription, mRNA processing, and the differentiation of nerve…

Gliocytoma

NAZ2329 is an Allosteric Inhibitor of R5 RPTP Subfamily and PTPRZ/PTPRG

Louis Gilman March 4, 2021

The R5 subfamily of receptor protein tyrosine phosphatases (RPTPs) includes PTPRZ and PTPRG. Specifically, PTPRZ1 is a member of the receptor tyrosine phosphatase family. Besides, PTPRZ1 encodes a one-way type…

Glioblastoma Gliocytoma

PINT87aa, a Potential Tumor-Suppressive Peptide, Directly Interacts with the PAF1 Complex

Louis Gilman February 4, 2021

Circular RNAs (circRNAs) are a large class of transcripts in the mammalian genome.  CircRNAs are inherently resistant to exonuclease activity (resulting in higher stability than linear RNAs) and often show tissue-…

Gliocytoma

RapaLink-1, a Third-Generation Bivalent mTOR Inhibitor, Combines Rapamycin with MLN0128

Louis Gilman September 23, 2020

Glioblastoma (GBM), the most common primary brain tumor, represents one of the most aggressive cancers. The signaling from PI3K and AKT to mTOR is commonly dysregulated in GBM. But, blockade…

Glioblastoma Gliocytoma

AMG-458 is a Selective and Orally Bioavailable c-Met Inhibitor

Louis Gilman July 29, 2020

C-met is a protein encoded by a met gene in humans, which has tyrosine kinase activity. Specifically, Met is an essential one-way tyrosine kinase receptor for embryonic development, organogenesis, and…

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  • JNJ-38877605 is an Orally Active c-Met Inhibitor for Solid Tumour Research
  • OATD-02 is an Orally Active Arginase 1/2 Inhibitor for Melanoma Research
  • INCB086550 is an Orally Active PD-L1 Inhibitor for Multiple Cancers Research
  • Panobinostat is a HDAC Inhibitor for Multiple Myeloma Research

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You Missed

Breast Cancer

BI 7446 is a STING Agonist for Immuno-oncology Research

Gastric Cancer Obesity

JNJ-38877605 is an Orally Active c-Met Inhibitor for Solid Tumour Research

Multiple Myeloma Myeloma

OATD-02 is an Orally Active Arginase 1/2 Inhibitor for Melanoma Research

autoimmune disease

INCB086550 is an Orally Active PD-L1 Inhibitor for Multiple Cancers Research

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