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Reliable, unbiased and up to date information in cancer research

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Lung Cancer Non-Small Cell Lung Cancer

GNE-618 is a Orally Active NAMPT Inhibitor

Louis Gilman November 28, 2019

Nicotinamide adenine dinucleotide (NAD) is a critical metabolite for a range of cellular reactions. NAD is an essential coenzyme involved in cellular redox reactions and is a substrate for NAD-dependent…

Lung Cancer Solid Tumors

S516 is a Potent Tubulin Polymerization Inhibitor

Louis Gilman November 25, 2019

The microtubules act as an attractive target for anticancer drug discovery nowadays. Disruption of microtubules can induce cell cycle arrest in the G2-M phase and formation of abnormal mitotic spindles.…

Liver Cancer

AC-73 is a Specific and Orally Active CD147 Dimerization Inhibitor

Louis Gilman November 24, 2019

Hepatocellular carcinoma (HCC) is one of the most common cancers. Combating hepatocellular carcinoma invasion and metastasis has become a major desire in hepatocellular carcinoma patients. CD147 (also called EMMPRIN) is…

Breast Cancer

DS18561882 is Selective and Orally Active MTHFD2 Inhibitor

Louis Gilman November 22, 2019

The human mitochondrial enzyme, called methylenetetrahydrofolate dehydrogenase 2 (MTHFD2), plays a key role in one-carbon metabolism in purine or thymidine biosynthesis. In mitochondrial folate carbon metabolism, MTHFD2 has attracted considerable…

Breast Cancer

CP5V is a Specific PROTAC Degrader of Cdc20

Louis Gilman November 20, 2019

The cell-division cycle protein 20 (Cdc20) is the substrate receptor of anaphase synthesis complex (APC) or cyclosome (APC/C). Besides, it coordinates late initiation and exit of mitosis through safety and…

Prostate Cancer

AG-825, a selective ErbB2 inhibitor with anti-cancer effect

Louis Gilman November 18, 2019

The ErbB tyrosine kinase receptor (RTK) family has 4 members: ErbB1 (EGFR/HER1), ErbB2 (HER2/neu), ErbB3 (HER3), and ErbB4 (HER4). These receptors are cell surface receptors and play important roles in…

Colon Adenocarcinoma Lung Adenocarcinoma Solid Tumors

MRTX849 is an Orally Active and Covalent Inhibitor of KRAS G12C

Louis Gilman November 17, 2019

KRAS mutations are the most common mutations. Especially, the KRAS oncogene encodes a binding protein that plays a crucial role in transmitting signals from extracellular growth factors to the cell…

Melanoma

IACS-8803 is a Cyclic Dinucleotide STING Agonist

Louis Gilman November 15, 2019

The stimulator of interferon genes (STING) is an innate pattern recognition receptor natively exists in the endoplasmic reticulum (ER). STING has a great effect on host defense through supervising pathogenic…

Gastric Cancer

SU16f is a Selective PDGFRβ Inhibitor for Gastric Cancer Therapy

Louis Gilman November 13, 2019

Mesenchymal stem cells (MSCs) are multipotent progenitor cells that play a critical role in tissue regeneration. MSCs play an important role in matrix remodeling, fibroblast activation, angiogenesis, and immunomodulation. MSCs…

Cancer

JNJ-10198409, an orally active PDGF-RTK inhibitor

Louis Gilman November 11, 2019

As we all know, angiogenesis plays an essential role in the physiology of neonatal development, reproduction, and wound healing. PDGF-BB (Platelet-derived growth factor-BB ) is a mitogenic factor for smooth…

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You Missed

Breast Cancer

BI 7446 is a STING Agonist for Immuno-oncology Research

Gastric Cancer Obesity

JNJ-38877605 is an Orally Active c-Met Inhibitor for Solid Tumour Research

Multiple Myeloma Myeloma

OATD-02 is an Orally Active Arginase 1/2 Inhibitor for Melanoma Research

autoimmune disease

INCB086550 is an Orally Active PD-L1 Inhibitor for Multiple Cancers Research

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