GNE-618 is a Orally Active NAMPT Inhibitor
Nicotinamide adenine dinucleotide (NAD) is a critical metabolite for a range of cellular reactions. NAD is an essential coenzyme involved in cellular redox reactions and is a substrate for NAD-dependent…
S516 is a Potent Tubulin Polymerization Inhibitor
The microtubules act as an attractive target for anticancer drug discovery nowadays. Disruption of microtubules can induce cell cycle arrest in the G2-M phase and formation of abnormal mitotic spindles.…
AC-73 is a Specific and Orally Active CD147 Dimerization Inhibitor
Hepatocellular carcinoma (HCC) is one of the most common cancers. Combating hepatocellular carcinoma invasion and metastasis has become a major desire in hepatocellular carcinoma patients. CD147 (also called EMMPRIN) is…
DS18561882 is Selective and Orally Active MTHFD2 Inhibitor
The human mitochondrial enzyme, called methylenetetrahydrofolate dehydrogenase 2 (MTHFD2), plays a key role in one-carbon metabolism in purine or thymidine biosynthesis. In mitochondrial folate carbon metabolism, MTHFD2 has attracted considerable…
CP5V is a Specific PROTAC Degrader of Cdc20
The cell-division cycle protein 20 (Cdc20) is the substrate receptor of anaphase synthesis complex (APC) or cyclosome (APC/C). Besides, it coordinates late initiation and exit of mitosis through safety and…
AG-825, a selective ErbB2 inhibitor with anti-cancer effect
The ErbB tyrosine kinase receptor (RTK) family has 4 members: ErbB1 (EGFR/HER1), ErbB2 (HER2/neu), ErbB3 (HER3), and ErbB4 (HER4). These receptors are cell surface receptors and play important roles in…
MRTX849 is an Orally Active and Covalent Inhibitor of KRAS G12C
KRAS mutations are the most common mutations. Especially, the KRAS oncogene encodes a binding protein that plays a crucial role in transmitting signals from extracellular growth factors to the cell…
IACS-8803 is a Cyclic Dinucleotide STING Agonist
The stimulator of interferon genes (STING) is an innate pattern recognition receptor natively exists in the endoplasmic reticulum (ER). STING has a great effect on host defense through supervising pathogenic…
SU16f is a Selective PDGFRβ Inhibitor for Gastric Cancer Therapy
Mesenchymal stem cells (MSCs) are multipotent progenitor cells that play a critical role in tissue regeneration. MSCs play an important role in matrix remodeling, fibroblast activation, angiogenesis, and immunomodulation. MSCs…
JNJ-10198409, an orally active PDGF-RTK inhibitor
As we all know, angiogenesis plays an essential role in the physiology of neonatal development, reproduction, and wound healing. PDGF-BB (Platelet-derived growth factor-BB ) is a mitogenic factor for smooth…