Topotecan is a Topo I Inhibitor for Kinds of Cancers Research
Lung cancer is a malignant disease with a high mortality rate and a poor prognosis. It is easy to metastasis and recurrence. Non-small cell lung cancer (NSCLC) is the most…
Lung cancer is a malignant disease with a high mortality rate and a poor prognosis. It is easy to metastasis and recurrence. Non-small cell lung cancer (NSCLC) is the most…
Galeterone (TOK-001) is a multifunctional antiandrogen and CYP17 inhibitor for castration resistant prostate cancer (CRPC) research.
Acetaminophen (Paracetamol) is a potent and selective cyclooxygenase-2 (COX-2) inhibitor for cancer and acute liver injury research.
R162 is a potent glutamate dehydrogenase 1 (GDH1/GLUD1) inhibitor and is used for kinds of cancers research.
ATG4B is a cysteine protease that activates LC3 for lipidation and recent studies suggest that it may be another promising target to inhibit autophagy upstream of the lysosome. Consistent with…
DNA dependent protein kinase (DNA-PK) is a serine/threonine protein kinase composed of catalytic subunits (DNA-PKcs) and Ku heterodimers composed of Ku70 and Ku80 subunits. Specifically, DNA-PK plays an important role…
Tivantinib, a c-MET inhibitor, is investigated as a second-line treatment of hepatocellular carcinoma (HCC). It was shown that c-MET overexpression predicts its efficacy. However, recent evidence indicates that the anticancer…
BRAFV600E is the most frequent mutation in BRAF (serine/threonine-protein kinase B-raf). It is a proto-oncogene and the most commonly mutated kinase in human cancers. BRAFV600E can be detected in glioma,…
The nuclear retinoic acid receptors (RARs) are transcriptional transregulators, which control the expression of specific gene subsets subsequently to ligand binding and to strictly controlled phosphorylation processes. RARs consist of…
Serotonin (5-HT) is a neurotransmitter that plays an important physiological role in the human body. Specifically, serotonin is the primary therapeutic target for many mental and neurological disorders associated with…