Proteasomes are very large protein complexes inside all eukaryotes and archaea, and in some bacteria. In eukaryotes, they are located in the nucleus and the cytoplasm. The main function of…
BBDDL2059 is a highly potent and selective covalent inhibitor of EZH2.
mTOR (mammalian target of Rapamycin) is a protein that in humans is encoded by the mTOR gene. Then, mTOR is a serine/threonine protein kinase that regulates cell growth, cell proliferation,…
The retinoid X receptor (RXR) belongs to the nuclear receptor superfamily. The nuclear receptors superfamily has many other nuclear receptors, including the retinoic acid receptor (RAR), vitamin D receptor (VDR),…
The ubiquitous Gαq subunit, a known transducer of plasma membrane G protein-coupled receptors signaling, is a core modulator of mTORC1 and autophagy. The Gαq subunit is made up of four…
Onvansertib, a PLK1-specific ATP competitive inhibitor, blocks the phosphorylation of PLK1 substrates. Polo was first identified in Drosophila melanogaster. The family of polo-like serine/threonine kinases includes 5 members: PLK1, PLK2,…
Ovarian cancer (OC) is the eighth most common neoplasia in women, and the fifth leading cause of cancer-related deaths. Due to a lack of early stage detection, about 70% of…
MEK (Mitogen-activated protein kinase kinase, MAPKK) is a kinase enzyme that phosphorylates mitogen-activated protein kinases (MAPKs). Firstly, the activated MAPK leads to the phosphorylation of downstream transcription factors that regulate…
HDACs (Histone deacetylases) are a class of enzymes that remove acetyl groups (O=C-CH3) from an ε-N-acetyl lysine amino acid on histone. HDACs allow the histones to wrap the DNA more…
Onvansertib, a PLK1-specific ATP competitive inhibitor, blocks the phosphorylation of PLK1 substrates. Polo was first identified in Drosophila melanogaster. The family of polo-like serine/threonine kinases is conserved in nearly all…