Category: Cancer

ABT-510 is an Anti-Angiogenic Thrombospondin Peptide

Angiogenesis is the growth of new capillaries from existing blood vessels. Steps toward angiogenesis include protease production, endothelial cell migration, and proliferation, vascular tube formation, anastomosis of newly formed tubes, synthesis of a new basement membrane, and incorporation of pericytes and smooth muscle cells. The process of angiogenesis is...

BI-0474 is a Potent KRAS G12C inhibitor

K-Ras protein is a kind of GTPase. Specifically, it is a kind of enzyme that converts nucleotide guanosine triphosphate (GTP) to guanosine diphosphate (GDP). In this way, the K-Ras protein acts like a switch. Besides, KRAS is the most frequently changed homotype in NSCLC cases with RAS mutation. Moreover,...

JNJ-9350 is an inhibitor of Spermine Oxidase (SMOX)

Spermine oxidase (SMOX) is a highly inducible enzyme. Specifically, its imbalance can change polyamine homeostasis. SMOX, spermine spermidine acetyltransferase (SSAT), and acetyl polyamine oxidase (APAO) are the main enzymes regulating the reverse transformation of polyamines. Besides, SMOX and SSAT are highly inducible, but APAO is constitutively expressed. SMOX is...

CAM833 is a Potent BRCA2-RAD51 Interaction Orthosteric Inhibitor

RAD51, an essential eukaryotic DNA recombinase, promotes homologous pairing and strand exchange during homologous recombination (HR) and the recombinational repair of double-strand breaks. RAD51 protein is recruited onto the DNA break by BRCA2 and forms homopolymeric filaments that invade the homologous chromatid and use it as a template for...

RP-6685 is an Orally Active DNA Polθ Inhibitor

DNA polymerase theta (Polθ) is a unique, large (290 kDa) multifunctional A-family DNA polymerase that is required for DNA double-strand breaks (DSBs) repair through the microhomology-mediated end-joining (MMEJ) pathway. Importantly, MMEJ is intrinsically mutagenic, whereas break sites are often scarred with insertions and deletions. Besides, increasing evidence suggests that MMEJ is...

MPM-1, an Anticancer agent, is a Marine Eusynstyelamides Mimic

Autophagy  is the natural and conservative degradation of cells. Specifically, it can remove unnecessary or dysfunctional components through lysosomal-dependent regulation mechanisms. Besides, it allows the orderly degradation and recycling of cellular components. It eliminates molecular and subcellular elements through lysosomal-mediated degradation. This includes nucleic acids, proteins, lipids, and organelles...

GNE-9815 is a highly selective pan-RAF inhibitor, can be used to research KRAS mutant cancers

Rapidly accelerated fibrous sarcoma (RAF) kinases are a family of three serine/threonine-specific protein kinases associated with retroviral oncogenes. They play key roles in several cellular processes, including cell cycle progression, cell proliferation, cell metabolism, cell migration, cell differentiation, and apoptosis. Activation of RAF kinases requires interaction with RAS-GTPases. RAF...