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Reliable, unbiased and up to date information in cancer research

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Cancer Neuropathy

Lactacystin is a Proteasome Inhibitor for Cancer and Kinds of Diseases Research

Louis Gilman September 18, 2023

Proteasomes are very large protein complexes inside all eukaryotes and archaea, and in some bacteria. In eukaryotes, they are located in the nucleus and the cytoplasm. The main function of…

Cancer

BBDDL2059 is a EZH2 Inhibitor for Cancer Research

Louis Gilman September 11, 2023

BBDDL2059 is a highly potent and selective covalent inhibitor of EZH2.

Cancer

CC214-1 is a mTOR Inhibitor for Glioblastoma Research

Louis Gilman September 5, 2023

mTOR (mammalian target of Rapamycin) is a protein that in humans is encoded by the mTOR gene. Then, mTOR is a serine/threonine protein kinase that regulates cell growth, cell proliferation,…

Breast Cancer Cancer HER2+ Breast Cancer Lung Cancer

MSU-42011 is an Orally Active RXR Agonist for Cancer Research

Louis Gilman September 1, 2023

The retinoid X receptor (RXR) belongs to the nuclear receptor superfamily. The nuclear receptors superfamily has many other nuclear receptors, including the retinoic acid receptor (RAR), vitamin D receptor (VDR),…

Cancer Melanoma

FR900359 is a Gαq/11/14 Inhibitor for Melanoma and Cardiovascular Disease Research

Louis Gilman August 29, 2023

The ubiquitous Gαq subunit, a known transducer of plasma membrane G protein-coupled receptors signaling, is a core modulator of mTORC1 and autophagy. The Gαq subunit is made up of four…

Cancer

Onvansertib is an Orally Available PLK1 Inhibitor for Malignancies Research

Louis Gilman August 28, 2023

Onvansertib, a PLK1-specific ATP competitive inhibitor, blocks the phosphorylation of PLK1 substrates. Polo was first identified in Drosophila melanogaster. The family of polo-like serine/threonine kinases includes 5 members: PLK1, PLK2,…

Cancer Ovary Cancer

Rucaparib is an Orally Active PARP Inhibitor for Prostate Cancer Research

Louis Gilman August 25, 2023

Ovarian cancer (OC) is the eighth most common neoplasia in women, and the fifth leading cause of cancer-related deaths. Due to a lack of early stage detection, about 70% of…

Cancer

Cobimetinib is an Oral MEK1 Inhibitor for Melanoma Research

Louis Gilman August 24, 2023

MEK (Mitogen-activated protein kinase kinase, MAPKK) is a kinase enzyme that phosphorylates mitogen-activated protein kinases (MAPKs). Firstly, the activated MAPK leads to the phosphorylation of downstream transcription factors that regulate…

Breast Cancer Cancer

Tucidinostat is an Orally Active HDAC Inhibitor for Breast Cancer Research

Louis Gilman August 23, 2023

HDACs (Histone deacetylases) are a class of enzymes that remove acetyl groups (O=C-CH3) from an ε-N-acetyl lysine amino acid on histone. HDACs allow the histones to wrap the DNA more…

Cancer

Onvansertib is an Orally Available PLK1 Inhibitor for Malignancies Research

Louis Gilman August 22, 2023

Onvansertib, a PLK1-specific ATP competitive inhibitor, blocks the phosphorylation of PLK1 substrates. Polo was first identified in Drosophila melanogaster. The family of polo-like serine/threonine kinases is conserved in nearly all…

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  • JNJ-38877605 is an Orally Active c-Met Inhibitor for Solid Tumour Research
  • OATD-02 is an Orally Active Arginase 1/2 Inhibitor for Melanoma Research
  • INCB086550 is an Orally Active PD-L1 Inhibitor for Multiple Cancers Research
  • Panobinostat is a HDAC Inhibitor for Multiple Myeloma Research

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Breast Cancer

BI 7446 is a STING Agonist for Immuno-oncology Research

Gastric Cancer Obesity

JNJ-38877605 is an Orally Active c-Met Inhibitor for Solid Tumour Research

Multiple Myeloma Myeloma

OATD-02 is an Orally Active Arginase 1/2 Inhibitor for Melanoma Research

autoimmune disease

INCB086550 is an Orally Active PD-L1 Inhibitor for Multiple Cancers Research

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