Lumiracoxib is a Selective and Orally Active COX-2 Inhibitor and Nonselective NSAID
Prostaglandins play an important role in modulating both physiological and inflammatory processes. They can act as autocrine factors regulating platelet aggregation, vascular tone, and secretions. Additionally, the synthesis of prostaglandin depends on the activity of cyclooxygenase (COX). There are existing two isoforms: COX-1 and COX-2. They are highly homologous...
Multiple Tyrosine Kinases Inhibitor TAS-115
VEGF signaling via VEGF receptor is a pivotal factor for tumor angiogenesis that regulates tumor progression. However, VEGFR-targeted inhibitor monotherapies showed limited effects on various carcinomas. And even combination therapies with chemotherapeutic agents are unsatisfactory. MET is a receptor for HGF. The HGF-MET signaling also participated in regulating tumor progression,...