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Network of Cancer Research

Reliable, unbiased and up to date information in cancer research

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Reliable, unbiased and up to date information in cancer research

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Cancer

SHR2415 is a Selective and Orally Active ERK1/2 Inhibitor

Louis Gilman September 27, 2022

ERKs (extracellular signal-regulated kinases) are the original members of the mitogen-activated protein kinase (MAPK) family. They take part in the regulation of meiosis, mitosis, and postmitotic functions, thus, also influencing…

Gliocytoma Glioma

CP681301 is a Potent CDK5 Inhibitor

Louis Gilman September 26, 2022

CDKs (Cyclin-dependent kinases) are serine-threonine kinases first discovered for their role in regulating the cell cycle. They are also involved in regulating transcription, mRNA processing, and the differentiation of nerve…

Prostate Cancer

ARD-69 is a Potent PROTAC Androgen Receptor Degrader

Louis Gilman September 24, 2022

Androgen receptor (AR) is a ligand-dependent nuclear transcription factor and a member of the steroid hormone nuclear receptor family. In fact, AR has many biological functions and can control the…

Acute Leukemia Acute Myeloid Leukemia Cancer

TK4g is a JAK Inhibitor for Leukemia Cancer Research

Louis Gilman September 22, 2022

Janus kinase (JAK) is an intracellular non-receptor tyrosine kinase. There are four members of the JAK family: JAK1, JAK2, JAK3, and Tyrosine kinase 2 (TYK2). JAK can link cytokine signals…

Breast Cancer Cancer

Simmiparib is An Orally Active PARP1/2 Inhibitor

Louis Gilman September 21, 2022

Poly (ADP-ribose) polymerase (PARP), a family of proteins, is involved in various cellular processes such as DNA repair and programmed cell death. PARP is present in the cell nucleus. It…

Colorectal Cancer Lung Cancer Non-Small Cell Lung Cancer Pancreas Cancer

G12Si-5 is a K-Ras G12S Mutant Covalent Inhibitor

Louis Gilman September 20, 2022

KRAS (Kirsten rat sarcoma virus) is one of the most commonly altered oncogenes in human cancers. Recurrent oncogenic mutations in KRAS can reprogram glutamine metabolism to increase the production of…

Cancer

EAI001 is a Selective Mutant EGFR Allosteric Inhibitor

Louis Gilman September 17, 2022

Epidermal growth factor receptor (EGFR) belongs to the ErbB family of receptor tyrosine kinases (RTKs). Specifically, EGFR belongs to a receptor family, which contains three additional proteins, namely ErbB-2, ErbB-3,…

Lung Adenocarcinoma Lung Cancer

LCS3 is a Glutathione Disulfide Reductase (GSR) and TXNRD1 Inhibitor

Louis Gilman September 10, 2022

Glutathione Disulfide Reductase (GSR), also known as glutathione reductase (GR), catalyzes the reduction of glutathione disulfide (GSSG) to glutathione (GSH) in the presence of NADPH and flavin adenine dinucleotide (FAD).…

Cancer

SPH5030 is a Selective and Irreversible HER2 Inhibitor.

Louis Gilman September 9, 2022

HER2 is a member of the human epidermal growth factor receptor (HER/EGFR/ERBB) family. Importantly, HER2 plays a crucial role in the regulation of cell growth, differentiation, and survival. Specifically, HER2…

Fibrosarcoma Kidney Cancer

BLU2864 is An Orally Active PRKACA Kinase Inhibitor

Louis Gilman September 8, 2022

Fibrolamellar carcinoma (FLC) is a rare, difficult-to-treat liver cancer primarily affecting pediatric and adolescent patients. An analysis of FLC tumor samples shows that protein kinase A (PKA) alpha catalytic subunit (PRKACA) is…

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You Missed

Breast Cancer

BI 7446 is a STING Agonist for Immuno-oncology Research

Gastric Cancer Obesity

JNJ-38877605 is an Orally Active c-Met Inhibitor for Solid Tumour Research

Multiple Myeloma Myeloma

OATD-02 is an Orally Active Arginase 1/2 Inhibitor for Melanoma Research

autoimmune disease

INCB086550 is an Orally Active PD-L1 Inhibitor for Multiple Cancers Research

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