MMRi62, a Ferroptosis Inducer Targeting MDM2-MDM4
MDM2 and MDM4 have established cancer drug targets. Additionally, they are also inhibitors of p53 activity and are amplified in many cancer types. In particular, the targeting of MDM2–p53 interactions is a novel strategy that is pursued to unleash the antitumor activity of p53. Furthermore, there needs to cover...
Manzamine A, an Orally Active β-Carboline Alkaloid with Antiviru, Antimalarial and Anticancer Activities
AManzamine A is an orally active β-carboline alkaloid effective against HSV-1, Cancer, and Malaria. For HSV-1， It is estimated that approximately 80% of the population worldwide are carriers of HSV-1 and approximately 40% suffer from recurrent infections. Unfortunately, this recurrent nature is a leading cause of corneal disease and...