AManzamine A is an orally active β-carboline alkaloid effective against HSV-1, Cancer, and Malaria. For HSV-1， It is estimated that approximately 80% of the population worldwide are carriers of HSV-1…
STAT3 protein is a potential cytoplasmic transcription factor. Constitutive activation of signal transducer and activator of transcription 3 (STAT3) is related to the proliferation, survival, invasion, and angiogenesis of many…
Topoisomerases (DNA topoisomerases) are enzymes that catalyze changes in the topological state of DNA, regulating the overwinding or underwinding of DNA. Topoisomerases play essential roles in DNA replication, transcription, chromosome…
Uterine myomas and endometriosis are sex-hormone-dependent diseases. They affect up to 50-60% and 10-50% women of reproductive age, respectively. Endometriosis is an estrogen-dependent chronic inflammatory disease. The pathophysiology of this…
Oxidative stress reflects the imbalance between the systemic performance of reactive oxygen species (ROS) and the ability of biological systems to easily detoxify active intermediates or repair the resulting damage.…
Mitochondria provide cellular energy through its oxidative phosphorylation system, which needs to coordinate the expression of genes encoded by nuclear and mitochondrial genomes (mtDNA). Specifically, the transcription of mtDNA in…
Aurora kinases represent a serine/threonine kinase family crucial for cell-cycle control. In particular, Aurora kinases are important and indispensable in multiple steps of mitotic progression. Specifically, Aurora kinase A acts…
Cervical cancer is one of the most common cancers among women worldwide. Ro 90-7501 is an inhibitor of the amyloid β42 (Aβ42) fibril assembly. It is associated with Alzheimer’s disease.…
TP53 (p53) is the single most frequently altered gene in human cancers, with mutations being present in approximately 50% of all invasive tumors. Besides, p53 is mutated in at least…
Microtubules play a critical role in the proliferation of cancer cells. Meanwhile, microtubule dynamics is therefore one of the most productive therapeutic targets for cancer treatment. Microtubule-targeting agents can interfere…