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Network of Cancer Research

Reliable, unbiased and up to date information in cancer research

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Reliable, unbiased and up to date information in cancer research

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Manzamine A, an Orally Active β-Carboline Alkaloid with Antiviru, Antimalarial and Anticancer Activities

Louis Gilman December 22, 2022

AManzamine A is an orally active β-carboline alkaloid effective against HSV-1, Cancer, and Malaria. For HSV-1, It is estimated that approximately 80% of the population worldwide are carriers of HSV-1…

Cervical Cancer Triple-Negative Breast Cancer

STX-0119 is a Selective, Orally Active STAT3 Dimerization Inhibitor

Louis Gilman November 21, 2022

STAT3 protein is a potential cytoplasmic transcription factor. Constitutive activation of signal transducer and activator of transcription 3 (STAT3) is related to the proliferation, survival, invasion, and angiogenesis of many…

Cancer Cervical Cancer Leukemia

BNS-22 is a DNA Topoisomerase II Catalytic Inhibitor

Louis Gilman August 18, 2022

Topoisomerases (DNA topoisomerases) are enzymes that catalyze changes in the topological state of DNA, regulating the overwinding or underwinding of DNA. Topoisomerases play essential roles in DNA replication, transcription, chromosome…

Adenomyosis Cancer Metastases Cervical Cancer

Linzagolix is a potent, non-Peptide, and Orally Active GnRH Antagonist

Louis Gilman March 22, 2022

Uterine myomas and endometriosis are sex-hormone-dependent diseases. They affect up to 50-60% and 10-50% women of reproductive age, respectively. Endometriosis is an estrogen-dependent chronic inflammatory disease. The pathophysiology of this…

Breast Cancer Cervical Cancer Lung Cancer

Trolox, an Analogue of Vitamin E, Possesses Antioxidant Effect

Louis Gilman December 9, 2021

Oxidative stress reflects the imbalance between the systemic performance of reactive oxygen species (ROS) and the ability of biological systems to easily detoxify active intermediates or repair the resulting damage.…

Cervical Cancer Lung Cancer Non-Small Cell Lung Cancer

IMT1 is a First-in-Class Specific and Noncompetitive Human POLRMT Inhibitor

Louis Gilman March 13, 2021

Mitochondria provide cellular energy through its oxidative phosphorylation system, which needs to coordinate the expression of genes encoded by nuclear and mitochondrial genomes (mtDNA). Specifically, the transcription of mtDNA in…

Cervical Cancer

TAS-119 is a Selective and Orally Active Aurora A Inhibitor

Louis Gilman February 27, 2021

Aurora kinases represent a serine/threonine kinase family crucial for cell-cycle control. In particular, Aurora kinases are important and indispensable in multiple steps of mitotic progression. Specifically, Aurora kinase A acts…

Cervical Cancer

Ro 90-7501, a Radiosensitizer, is an Aβ42 Fibril Assembly and PP5 Inhibitor

Louis Gilman March 19, 2020

Cervical cancer is one of the most common cancers among women worldwide. Ro 90-7501 is an inhibitor of the amyloid β42 (Aβ42) fibril assembly. It is associated with Alzheimer’s disease.…

Breast Cancer Cervical Cancer Endometrial Cancer Head and Neck Cancer Ovary Cancer

COTI-2 is an Orally Available Mutant p53 Activator

Louis Gilman January 16, 2020

TP53 (p53) is the single most frequently altered gene in human cancers, with mutations being present in approximately 50% of all invasive tumors. Besides, p53 is mutated in at least…

Cervical Cancer Melanoma Prostate Cancer

VERU-111 is an Orally Active Tubulin Inhibitor

Louis Gilman August 10, 2019

Microtubules play a critical role in the proliferation of cancer cells. Meanwhile, microtubule dynamics is therefore one of the most productive therapeutic targets for cancer treatment. Microtubule-targeting agents can interfere…

Recent Posts

  • BI 7446 is a STING Agonist for Immuno-oncology Research
  • JNJ-38877605 is an Orally Active c-Met Inhibitor for Solid Tumour Research
  • OATD-02 is an Orally Active Arginase 1/2 Inhibitor for Melanoma Research
  • INCB086550 is an Orally Active PD-L1 Inhibitor for Multiple Cancers Research
  • Panobinostat is a HDAC Inhibitor for Multiple Myeloma Research

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You Missed

Breast Cancer

BI 7446 is a STING Agonist for Immuno-oncology Research

Gastric Cancer Obesity

JNJ-38877605 is an Orally Active c-Met Inhibitor for Solid Tumour Research

Multiple Myeloma Myeloma

OATD-02 is an Orally Active Arginase 1/2 Inhibitor for Melanoma Research

autoimmune disease

INCB086550 is an Orally Active PD-L1 Inhibitor for Multiple Cancers Research

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