Actinomycin D Inhibits DNA Repair and Induces Autophagy
Actinomycin D is isolated from Streptomyces species, containing a phenoxazine chromophore and two cyclic pentapeptide lactone rings. Besides, Actinomycin D can inhibit DNA repair, DNA-directed RNA synthesis, or DNA synthesis via binding to double-stranded DNA and the phenoxazine chromophore inserting DNA bases. Therefore, it acts as a DNA intercalator and...
LTX-315 is an Oncolytic Peptide with Potent Anticancer Activity
Oncolytic peptides offer yet a new therapeutic modality. Their membranolytic mode of action includes the release of danger-associated molecular pattern molecules (DAMPs) and tumor antigens from cancer cells. Therefore, it results in regression of solid tumors and systemic tumor-specific immune responses. Consequently, the development of oncolytic peptides into novel...
β-Amanitin is a cyclic peptide toxin, inhibits eukaryotic RNA polymerase II and III and protein synthesis.
β-Amanitin is a cyclic peptide toxin in the poisonous Amanita phalloides mushroom. Besides, β-Amanitin inhibits eukaryotic RNA polymerase II and III. It inhibits DNA transcription and protein synthesis. Moreover, β-Amanitin can be used as a cytotoxic component of antibody-drug conjugates (ADCs). β-Amanitin (0.01-100 µg/mL; 36 hours) shows toxicity in...
Vatalanib (PTK787) is an Inhibitor of VEGFR2/KDR
Vascular endothelial growth factor receptor (VEGFR) is the receptor for VEGF. VEGF is an important signaling protein involved in both vasculogenesis and angiogenesis. VEGFRs consist of three subtypes, the fms-like tyrosine kinase Flt-1 (VEGFR1/Flt-1), the kinase domain region, also referred to as fetal liver kinase (VEGFR2/KDR/Flk-1), and Flt-4 (VEGFR3)....
Gardiquimod is a TLR7/8 Agonist and Could Inhibit HIV-1 Infection
Toll-like receptors (TLR) are a family of highly conserved pattern recognition receptors. They participate in innate immune responses to pathogen infection. Some of the more than two dozen members of this class of receptors that include TLR3, TLR7, TLR8, and TLR9 are localized within intracellular vesicles including the endoplasmic...
Ascochlorin Mediates Anti-tumor Effects through the Suppression of STAT3 Signaling Cascade
Signal transducer and activator of transcription (STAT) protein is a family of cytoplasmic protein. STAT pathway is connected upstream with Janus kinases (JAK) family protein and capable of integrating inputs from different signaling pathways. The transcription factors of this family dysregulation of this pathway are present in primary tumours...
Marimastat (BB2516) is a Broad Spectrum and Orally Active Inhibitor of MMPs
Marimastat (BB2516) is a broad spectrum and orally bioavailable inhibitor of MMPs (Matrix metalloproteinases). Marimastat (BB2516) is an angiogenesis and metastasis inhibitor, which limits the growth and production of blood vessels. Besides, As an antimetastatic agent, it prevents malignant cells from breaching the basement membranes. Marimastat (BB2516) shows potent...