Solid tumors are dependent for growth on nutrients and oxygen they receive via angiogenesis, the process wherein new capillaries are formed from existing blood vessels. In addition, many studies demonstrated…
In almost half of hepatocellular carcinoma (HCC) cases, the Akt pathway is activated. Miransertib is a highly selective, orally active, pan-Akt inhibitor. Miransertib target all three Akt isoforms by blocking…
ErbB is a transmembrane receptor tyrosine protein kinase, ErbB receptor family. This family is a subfamily of four closely related receptor tyrosine kinases: EGFR (ErbB-1), HER2/neu (ErbB-2), Her 3 (ErbB-3),…
Microtubules are a component of the cytoskeleton. Microtubules are found in eukaryotic cells and are formed by the polymerization of a dimer of two globular proteins, alpha and beta tubulin.…
Mitogen-activated protein kinase (MAPKs) are a family of conservative protein serine/threonine kinases that respond to a variety of extracellular stimuli and participate in gene expression, cell metabolism, proliferation, differentiation, and…
The Bcl-2 family consists of a number of evolutionarily-conserved proteins that share Bcl-2 homology (BH) domains. And it is most notable for their regulation of apoptosis, a form of programmed…
Sorafenib is an oral multi-kinase inhibitor that inhibits cell proliferation through a strong inhibition of the serine/threonine kinase RAF. Sorafenib was initially approved by the FDA for treatment of metastatic…
Hedgehog (Hh) is composed of N-terminal and C-terminal domains that dissociate in a self-catalyzed proteolytic cleavage reaction. The Hedgehog signaling pathway is a signaling pathway that transmits information to embryonic…
Chk1 is a serine-threonine kinase, and plays a key role in G2M arrest, G1-S, intra S, and mitotic checkpoints. Usually, Chk1 is of high level in cancers, including lung cancer,…
mTOR, the mammalian target of rapamycin, is a conserved serine/threonine kinase. mTOR often serves as a catalytic subunit and consists of two protein complexes: mTOR complex 1 and mTOR complex…