YL5084 is a Covalent JNK Inhibitor for Multiple Myeloma Research.
JNK is involved in regulating another mitochondrial protein cytochrome c during cell apoptosis. Specifically, Smac is the second mitochondrial-derived caspase activator, which promotes cell apoptosis by activating caspase. Without NF-κB In the case of activation, prolonged JNK activation contributes to TNF-α Induced cell apoptosis. Besides, JNK is also essential...
NX-2127 is an Orally and Potent BTK Inhibitor for B-cell Malignancies Research
BTK (Bruton’s tyrosine kinase), is a Tec family tyrosine kinase. It plays a crucial role in B cell development and function. BTK has dual regulatory functions in B cell apoptosis, such as promoting radiation-induced apoptosis but inhibiting Fas-activated apoptosis. BTK is a key target in B-cell malignancies such as chronic...
Nintedanib (BIBF 1120) is a Tyrosine Kinase/Triple Angiokinase Inhibitor
Idiopathic pulmonary fibrosis (IPF) is a progressive fibrosing interstitial lung disease (ILD). Hence, the characteristics of IPF is self-sustaining fibrosis, deteriorating lung function, worsening symptoms (e.g. dyspnoea, cough), increasingly impaired health-related quality of life (HR-QOL) and premature mortality. However, the median survival from the time of diagnosis is 4.5...
Theliatinib tartrate is an Orally Active EGFR Inhibitor for Esophageal Cancer Research
EGFR stands for epidermal growth factor receptor, a tyrosine kinase and transmembrane receptor protein. It primarily functions to regulate epithelial tissue development and homeostasis. Moreover, EGFR is a driver of tumors. Specifically, it is often abnormally activated and overexpressed in cancer cells (such as esophageal cancer). EGFR selectively binds...
BPA-B9 is a RXRα Antagonist for Cancer Research
Retinoid X receptor alpha (RXR-alpha), also known as NR2B1, is a member of the retinoid x receptor (rxr) family, which is a group of transcription factors that regulate gene expression. Specifically, RXR-alpha forms heterodimers with other nuclear receptors, such as thyroid hormone receptors, vitamin D receptors, and peroxisome proliferator-activated receptors,...
LL-K8-22 is a CDK8-cyclin C Dual Degrader for TNBC Research
CDK8 is a transcription-associated cyclin-dependent protein kinase (CDK) and also is a colorectal cancer oncogene. Cyclin C is a member of the cyclin family of proteins. Besides, Cyclin C interacts with cyclin-dependent kinase 8 and induces the phosphorylation of the carboxy-terminal domain of the large subunit of RNA polymerase...
Adavosertib (AZD-1775) is a Potent Wee1 Inhibitor for Colon Cancer Research
The regulation of cell size is critical to ensure the functionality of a cell. Besides environmental factors such as nutrients, growth factors and functional load, cell size is also controlled by a cellular cell size checkpoint. Wee1 is a component of this checkpoint. It is a nuclear kinase belonging...