Acetaminophen is a Selective COX-2 Inhibitor for Cancer and Acute Liver Injury Research
Acetaminophen (Paracetamol) is a potent and selective cyclooxygenase-2 (COX-2) inhibitor for cancer and acute liver injury research.
Acetaminophen (Paracetamol) is a potent and selective cyclooxygenase-2 (COX-2) inhibitor for cancer and acute liver injury research.
R162 is a potent glutamate dehydrogenase 1 (GDH1/GLUD1) inhibitor and is used for kinds of cancers research.
The transmembrane proto-oncogene receptor tyrosine kinase (RTK) ROS is one of the last two remaining orphan receptor tyrosine kinases. The ectopic expression, as well as the production of variable mutant…
ATG4B is a cysteine protease that activates LC3 for lipidation and recent studies suggest that it may be another promising target to inhibit autophagy upstream of the lysosome. Consistent with…
Lung cancer is the uncontrolled proliferation of cells lining the air passages and tissues of the lungs. It is the second most common cancer in both men and women. It…
CSF-1R, a receptor protein-tyrosine kinase belonging to the PDGFR family, serves as a cell surface receptor for IL-34 and CSF1. It plays pivotal roles in haematopoiesis, proliferation regulation, cell survival,…
Cancer immunotherapy, particularly PD-1/PD-L1 blockade, has seen remarkable success. However, patients can develop adaptive resistance to this treatment. To improve efficacy, combination strategies like pairing PD-1/PD-L1 blockade with radiotherapy or…
The epidermal growth factor receptor (EGFR) is a transmembrane protein that is a receptor for members of the epidermal growth factor family (EGF family) of extracellular protein ligands. The EGFR…
Androgen receptor (AR) is a type of nuclear receptor that is activated by binding of either of the androgenic hormones testosterone or dihydrotestosterone in the cytoplasm and then translocating into…
DNA dependent protein kinase (DNA-PK) is a serine/threonine protein kinase composed of catalytic subunits (DNA-PKcs) and Ku heterodimers composed of Ku70 and Ku80 subunits. Specifically, DNA-PK plays an important role…