PTC299 is an Oral Active and Dual Inhibitor of DHODH and VEGF
De novo pyrimidine nucleotide biosynthesis is activated in proliferating cancer cells in response to an increased demand for synthesis of DNA, RNA and phospholipids. The synthesis activates via oncogenic pathways, such as Myc, PI3K, PTEN and mTOR. Dihydroorotate dehydrogenase (DHODH) locates on the surface of the inner mitochondrial membrane,...