SIS3 is a Potent and Selective Inhibitor of Smad3 Phosphorylation
Smad contains a series of proteins with similar structures, which are the main signal transducer in transforming growth factors β (TGF-b) superfamily. Specifically, they play an important role in the regulation of cell development and growth. One mechanism of Smads promoting TGF-b-induced cell arrest is down-regulation of Myc, a...