A 83-01 is a Potent Inhibitor of TGF-β Type I Receptor ALK5 Kinase
TGF-β, activin, nodal, and bone morphogenetic proteins (BMPs) belong to the TGF-β superfamily. It regulates a wide range of cellular responses, including cell proliferation, differentiation, adhesion, migration, and apoptosis. TGF-β and related proteins transduce signals through two distinct serine/threonine kinase receptors, including type I and type II. The function...
EW-7195 is a Specific ALK5 (TGFβR1) Inhibitor with Anti-Metastasis Activity
Breast cancer is the leading cause of cancer mortality among women in Korea, England, and the United States of America. Invasion and metastasis are the most lethal characteristics of breast cancer. TGF-β signaling maintains homeostasis and elicits tumor-suppressive responses such as growth inhibition and apoptosis in normal mammary epithelial...