GSK621 is a Specific AMPK Activator, Inducing Autophagy and Apoptosis
AMPK is an enzyme, which plays a role in cell energy homeostasis. It mainly activates glucose and fatty acid uptake and oxidation when the cell energy is low. Specifically, AMPK is a major regulator of cell metabolism, which can exert its carcinogenic or antitumor activities. Besides, the activation of...
ASP4132 is an Orally Active AMPK Activator
Adenosine monophosphate (AMP)-activated protein kinase (AMPK) is an enzyme that plays a role in cellular energy homeostasis. Specifically, it is important in largely to activate glucose and fatty acid uptake and oxidation when cellular energy is low. Besides, AMP or adenosine diphosphate (ADP) levels increase during metabolic stress such...
MRT199665 is a ATP-Competitive MARK/SIK/AMPK Inhibitor
In acute myeloid leukemia (AML), chemotherapy resistance remains prevalent and poorly understood. AML are cancers of the blood. They originate in the hematopoietic progenitor cells as a result of the accumulation of genetic mutations that lead to cell transformation. Prevalence of mutations of genes encoding regulators of gene expression...
DK419 Is a Potent Inhibitor of Wnt/β-Catenin Signaling for Colorectal Cancer Treatment
Colorectal Cancer (bowel cancer; colon cancer) is one of the most serious cancer diseases, with the development from colon or rectum. It is mainly due to old age and environmental factors. Although we have discovered batches of anti-cancer agents, they are still lacking. Wnt/β-Catenin signaling is a canonical Wnt...