Tag: anti-cancer

SPH5030 is a Selective and Irreversible HER2 Inhibitor.

HER2 is a member of the human epidermal growth factor receptor (HER/EGFR/ERBB) family. Importantly, HER2 plays a crucial role in the regulation of cell growth, differentiation, and survival. Specifically, HER2 is the only member in the HER family without a specific ligand, so its overexpression accordingly can lead to...

AZD-9574 is a potent and brain penetrant PARP1 inhibitor

The Poly (ADP-ribose) polymerase (PARP) family has numerous essential functions. PARP plays roles in cellular processes such as transcription, chromatin remodeling, DNA damage response, and repair. DNA double-strand breaks (DSBs) are the most deleterious form of DNA damage. Besides, DSBs can be repaired by homologous recombination repair (HRR) or...