Acolbifene (EM-652), is an Orally Active Selective Estrogen Receptor Antagonist
There are two different forms of the estrogen receptor ERα and ERβ. Acolbifene (EM-652) is an orally active selective estrogen receptor antagonist. In particular, Acolbifene is a cancer-preventing selective estrogen receptor modulator (SERM). Acolbifene exerts a potent and pure anti-estrogenic action in the mammary gland and uterus. In addition,...
GW7604, the Metabolite of GW5638, is a Selective Estrogen Receptor Downregulator (SERD)
Drugs that inhibit estrogen receptor alpha (ERα) or which block the production of estrogens remain frontline interventions in the treatment and management of breast cancer at all stages. In this study, researchers found that molecular mechanism of action at estrogen receptor α of GW7604. GW7604 is a clinically relevant...