TNP-351, an Antifolate, is a Dihydrofolate Reductase (DHFR) Inhibitor
Antifolates are a class of antimetabolite medications that block the actions of folic acid. Antimalarial antifolates have been central for prophylaxis and treatment of malaria. The success of antifolates in the treatment of tumors also leads to the use of this class of drugs in the treatment of other...
LSN 3213128 is an Orally Active AICARFT Inhibitor
Antifolates are a group of antimetabolite agents, which block the functions of folic acid. Folic acid is a cofactor to different kinds of methyltransferases. The latter are related to serine, methionine, thymidine and purine biosynthesis. Thus, antifolates are able to inhibit cell division, DNA/RNA synthesis and repair as well...