Tag: antiproliferative

DC-S239 is a Selective SET7 Inhibitor With Anti-Cancer Activity

SET7 is a protein lysine methyltransferase (PKMT), which methylates a plethora of proteins and regulates diverse biological processes. Meanwhile, SET7 plays a significant role in transcriptional regulation, cell cycle control, differentiation, DNA repair, and DNMT1 stability. Specifically, researches show that SET7 is closely associated with various diseases. Particularly, SET7...

BM-1074 is a Potent and Specific Bcl-2/Bcl-xL Inhibitor

Bcl-2 (B-cell lymphoma 2) and Bcl-xL (B-cell lymphoma-extra large) are members of the Bcl-2 family of proteins. BCL-2 is localized to the outer membrane of mitochondria, where it plays an important role in promoting cell survival and inhibiting the actions of pro-apoptotic proteins. As well as, Bcl-xL acts as an...